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10.15252/embj.201490805 http://scihub22266oqcxt.onion/10.15252/embj.201490805 C4406653!4406653 !25712475     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25712475 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2015 ; 34 (8 ): 1078-89 Nephropedia Template TP {{tp|p=25712475 |t=2015. Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells |pdf=|usr=}}{{25712475 }} gab.com Text Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25712475 #FOAvip Mucociliary clearance and fluid transport along epithelial surfaces are carried out by multiciliated cells (MCCs). Recently, human mutations in Cyclin O (CCNO) were linked to severe airway disease. Here, we show that Ccno expression is restricted to MCCs and the genetic deletion of Ccno in mouse leads to reduced numbers of multiple motile cilia and characteristic phenotypes of MCC dysfunction including severe hydrocephalus and mucociliary clearance deficits. Reduced cilia numbers are caused by compromised generation of centrioles at deuterosomes, which serve as major amplification platform for centrioles in MCCs. Ccno-deficient MCCs fail to sufficiently generate deuterosomes, and only reduced numbers of fully functional centrioles that undergo maturation to ciliary basal bodies are formed. Collectively, this study implicates CCNO as first known regulator of deuterosome formation and function for the amplification of centrioles in MCCs. Twit Text FOAVip Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25712475 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25712475 #FOAvip English Wikipedia <ref>{{Cite pmid|25712475 }}</ref> Cyclin O (Ccno) functions during deuterosome-mediated centriole amplification of multiciliated cells #MMPMID25712475 Funk MC ; Bera AN ; Menchen T ; Kuales G ; Thriene K ; Lienkamp SS ; Dengjel J ; Omran H ; Frank M ; Arnold SJ EMBO J 2015[Apr]; 34 (8 ): 1078-89 PMID25712475 show ga Mucociliary clearance and fluid transport along epithelial surfaces are carried out by multiciliated cells (MCCs). Recently, human mutations in Cyclin O (CCNO) were linked to severe airway disease. Here, we show that Ccno expression is restricted to MCCs and the genetic deletion of Ccno in mouse leads to reduced numbers of multiple motile cilia and characteristic phenotypes of MCC dysfunction including severe hydrocephalus and mucociliary clearance deficits. Reduced cilia numbers are caused by compromised generation of centrioles at deuterosomes, which serve as major amplification platform for centrioles in MCCs. Ccno-deficient MCCs fail to sufficiently generate deuterosomes, and only reduced numbers of fully functional centrioles that undergo maturation to ciliary basal bodies are formed. Collectively, this study implicates CCNO as first known regulator of deuterosome formation and function for the amplification of centrioles in MCCs. |Animals [MESH] |Cell Differentiation/genetics [MESH] |Cells, Cultured [MESH] |Centrioles/*physiology/ultrastructure [MESH] |Cilia/physiology/ultrastructure [MESH] |Cyclins/*physiology [MESH] |Embryo, Mammalian [MESH] |Gene Expression Regulation, Developmental [MESH] |Hydrocephalus/embryology/genetics [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Mucociliary Clearance/genetics [MESH] |Organogenesis/genetics [MESH]Cyclin O (Ccno) functions during deuterosome-mediated centriole amplif(epmc).pdf DeepDyve Pubget Overpricing