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10.3332/ecancer.2015.521 http://scihub22266oqcxt.onion/10.3332/ecancer.2015.521 C4406527!4406527!25932045     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ecancermedicalscience 2015 ; 9 (ä): ä Nephropedia Template TP {{tp|p=25932045|t=2015. Repurposing Drugs in Oncology (ReDO)?itraconazole as an anti-cancer agent |pdf=|usr=}}{{25932045}} gab.com Text Repurposing Drugs in Oncology (ReDO) itraconazole as an anti-cancer agent JO: Ecancermedicalscience http://www.kidney.de/pget.php?&tw=1&pmid=25932045 #FOAvip Itraconazole, a common triazole anti-fungal drug in widespread clinical use, has evidence of clinical activity that is of interest in oncology. There is evidence that at the clinically relevant doses, itraconazole has potent anti-angiogenic activity, and that it can inhibit the Hedgehog signalling pathway and may also induce autophagic growth arrest. The evidence for these anticancer effects, in vitro, in vivo, and clinical are summarised, and the putative mechanisms of their action outlined. Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. Given the evidence presented, a case is made that itraconazole warrants further clinical investigation as an anti- cancer agent. Additionally, based on the properties summarised previously, it is proposed that itraconazole may synergise with a range of other drugs to enhance the anti-cancer effect, and some of these possible combinations are presented in the supplementary materials accompanying this paper. Twit Text FOAVip Repurposing Drugs in Oncology (ReDO) itraconazole as an anti-cancer agent ????Ecancermedicalscience http://www.kidney.de/pget.php?&tw=1&pmid=25932045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25932045 #FOAvip English Wikipedia <ref>{{Cite pmid|25932045}}</ref> Repurposing Drugs in Oncology (ReDO)?itraconazole as an anti-cancer agent #MMPMID25932045 Pantziarka P; Sukhatme V; Bouche G; Meheus L; Sukhatme VP Ecancermedicalscience 2015[]; 9 (ä): ä PMID25932045show ga Itraconazole, a common triazole anti-fungal drug in widespread clinical use, has evidence of clinical activity that is of interest in oncology. There is evidence that at the clinically relevant doses, itraconazole has potent anti-angiogenic activity, and that it can inhibit the Hedgehog signalling pathway and may also induce autophagic growth arrest. The evidence for these anticancer effects, in vitro, in vivo, and clinical are summarised, and the putative mechanisms of their action outlined. Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. Given the evidence presented, a case is made that itraconazole warrants further clinical investigation as an anti- cancer agent. Additionally, based on the properties summarised previously, it is proposed that itraconazole may synergise with a range of other drugs to enhance the anti-cancer effect, and some of these possible combinations are presented in the supplementary materials accompanying this paper. äRepurposing Drugs in Oncology (ReDO)?itraconazole as an anti-cancer ag(epmc).pdf DeepDyve Pubget Overpricing