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10.1146/annurev-genom-090613-094245 http://scihub22266oqcxt.onion/10.1146/annurev-genom-090613-094245 C4406255!4406255!25184531     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Genomics+Hum+Genet 2014 ; 15 (ä): 269-93 Nephropedia Template TP {{tp|p=25184531|t=2014. Mendelian Disorders of the Epigenetic Machinery: Tipping the Balance of Chromatin States |pdf=|usr=}}{{25184531}} gab.com Text Mendelian Disorders of the Epigenetic Machinery: Tipping the Balance of Chromatin States JO: Annu Rev Genomics Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=25184531 #FOAvip Mendelian disorders of the epigenetic machinery are a newly delineated group of multiple congenital anomaly and intellectual disability syndromes resulting from mutations in genes encoding components of the epigenetic machinery. The gene products affected in these inherited conditions act in trans and are expected to have widespread epigenetic consequences. Many of these syndromes demonstrate phenotypic overlap with classical imprinting disorders and with one another. The various writer and eraser systems involve opposing players, which we propose must maintain a balance between open and closed chromatin states in any given cell. An imbalance might lead to disrupted expression of disease-relevant target genes. We suggest that classifying disorders based on predicted effects on this balance would be informative regarding pathogenesis. Furthermore, strategies targeted at restoring this balance might offer novel therapeutic avenues, taking advantage of available agents such as histone deacetylase inhibitors and histone acetylation antagonists. Twit Text FOAVip Mendelian Disorders of the Epigenetic Machinery: Tipping the Balance of Chromatin States ????Annu Rev Genomics Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=25184531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25184531 #FOAvip English Wikipedia <ref>{{Cite pmid|25184531}}</ref> Mendelian Disorders of the Epigenetic Machinery: Tipping the Balance of Chromatin States #MMPMID25184531 Fahrner JA; Bjornsson HT Annu Rev Genomics Hum Genet 2014[]; 15 (ä): 269-93 PMID25184531show ga Mendelian disorders of the epigenetic machinery are a newly delineated group of multiple congenital anomaly and intellectual disability syndromes resulting from mutations in genes encoding components of the epigenetic machinery. The gene products affected in these inherited conditions act in trans and are expected to have widespread epigenetic consequences. Many of these syndromes demonstrate phenotypic overlap with classical imprinting disorders and with one another. The various writer and eraser systems involve opposing players, which we propose must maintain a balance between open and closed chromatin states in any given cell. An imbalance might lead to disrupted expression of disease-relevant target genes. We suggest that classifying disorders based on predicted effects on this balance would be informative regarding pathogenesis. Furthermore, strategies targeted at restoring this balance might offer novel therapeutic avenues, taking advantage of available agents such as histone deacetylase inhibitors and histone acetylation antagonists. äMendelian Disorders of the Epigenetic Machinery: Tipping the Balance o(epmc).pdf DeepDyve Pubget Overpricing