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10.1002/wsbm.1295 http://scihub22266oqcxt.onion/10.1002/wsbm.1295 C4406149!4406149!25808551     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Wiley+Interdiscip+Rev+Syst+Biol+Med 2015 ; 7 (3): 113-29 Nephropedia Template TP {{tp|p=25808551|t=2015. Integrative models of vascular remodeling during tumor growth |pdf=|usr=}}{{25808551}} gab.com Text Integrative models of vascular remodeling during tumor growth JO: Wiley Interdiscip Rev Syst Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=25808551 #FOAvip Malignant solid tumors recruit the blood vessel network of the host tissue for nutrient supply, continuous growth, and gain of metastatic potential. Angiogenesis (the formation of new blood vessels), vessel cooption (the integration of existing blood vessels into the tumor vasculature), and vessel regression remodel the healthy vascular network into a tumor-specific vasculature that is in many respects different from the hierarchically organized arterio-venous blood vessel network of the host tissues. Integrative models based on detailed experimental data and physical laws implement in silico the complex interplay of molecular pathways, cell proliferation, migration, and death, tissue microenvironment, mechanical and hydrodynamic forces, and the fine structure of the host tissue vasculature. With the help of computer simulations high-precision information about blood flow patterns, interstitial fluid flow, drug distribution, oxygen and nutrient distribution can be obtained and a plethora of therapeutic protocols can be tested before clinical trials. In this review, we give an overview over the current status of integrative models describing tumor growth, vascular remodeling, blood and interstitial fluid flow, drug delivery, and concomitant transformations of the microenvironment. © 2015 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals, Inc. Twit Text FOAVip Integrative models of vascular remodeling during tumor growth ????Wiley Interdiscip Rev Syst Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=25808551 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25808551 #FOAvip English Wikipedia <ref>{{Cite pmid|25808551}}</ref> Integrative models of vascular remodeling during tumor growth #MMPMID25808551 Rieger H; Welter M Wiley Interdiscip Rev Syst Biol Med 2015[May]; 7 (3): 113-29 PMID25808551show ga Malignant solid tumors recruit the blood vessel network of the host tissue for nutrient supply, continuous growth, and gain of metastatic potential. Angiogenesis (the formation of new blood vessels), vessel cooption (the integration of existing blood vessels into the tumor vasculature), and vessel regression remodel the healthy vascular network into a tumor-specific vasculature that is in many respects different from the hierarchically organized arterio-venous blood vessel network of the host tissues. Integrative models based on detailed experimental data and physical laws implement in silico the complex interplay of molecular pathways, cell proliferation, migration, and death, tissue microenvironment, mechanical and hydrodynamic forces, and the fine structure of the host tissue vasculature. With the help of computer simulations high-precision information about blood flow patterns, interstitial fluid flow, drug distribution, oxygen and nutrient distribution can be obtained and a plethora of therapeutic protocols can be tested before clinical trials. In this review, we give an overview over the current status of integrative models describing tumor growth, vascular remodeling, blood and interstitial fluid flow, drug delivery, and concomitant transformations of the microenvironment. © 2015 The Authors. WIREs Systems Biology and Medicine published by Wiley Periodicals, Inc. äIntegrative models of vascular remodeling during tumor growth (epmc).pdf DeepDyve Pubget Overpricing