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10.1111/jvh.12311 http://scihub22266oqcxt.onion/10.1111/jvh.12311 C4406130!4406130!25219291     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Viral+Hepat 2015 ; 22 (4): 376-83 Nephropedia Template TP {{tp|p=25219291|t=2015. Cost-effectiveness of sofosbuvir in the treatment of patients with hepatitis C |pdf=|usr=}}{{25219291}} gab.com Text Cost-effectiveness of sofosbuvir in the treatment of patients with hepatitis C JO: J Viral Hepat http://www.kidney.de/pget.php?&tw=1&pmid=25219291 #FOAvip In France, 190 306 patients were suffering from chronic hepatitis C in 2012. These patients have a decreased life expectancy and are susceptible to complications associated with chronic hepatitis. Current treatments are poorly tolerated and their effectiveness varies depending on the genotype of the virus. Sofosbuvir, a new class of treatment, has demonstrated in five phase III trials sustained viral response (SVR) rates of over 90% across genotypes, higher than current treatments and has a tolerance profile similar to placebo. The objective was to determine the cost-effectiveness of using sofosbuvir in the treatment of chronic HCV infection. A Markov model was used to compare treatment strategies with and without sofosbuvir. The model simulated the natural history of HCV infection. SVR rates were based on data from clinical trials. Utilities associated with different stages of disease were based on data from the literature. French direct medical costs were used. Price for sofosbuvir was the price used in the early access program for severe fibrosis stages. The incremental cost?effectiveness ratio for sofosbuvir versus current reference treatments was ? 16 278/QALY and varied from 40 000 ?/QALY for F0 stages to 12 080 ?/QALY for F4 stages. The sensitivity analyses carried out confirmed the robustness of this result. Sofosbuvir is a cost-effective treatment option for patients with hepatitis C. Twit Text FOAVip Cost-effectiveness of sofosbuvir in the treatment of patients with hepatitis C ????J Viral Hepat http://www.kidney.de/pget.php?&tw=1&pmid=25219291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25219291 #FOAvip English Wikipedia <ref>{{Cite pmid|25219291}}</ref> Cost-effectiveness of sofosbuvir in the treatment of patients with hepatitis C #MMPMID25219291 Leleu H; Blachier M; Rosa I J Viral Hepat 2015[Apr]; 22 (4): 376-83 PMID25219291show ga In France, 190 306 patients were suffering from chronic hepatitis C in 2012. These patients have a decreased life expectancy and are susceptible to complications associated with chronic hepatitis. Current treatments are poorly tolerated and their effectiveness varies depending on the genotype of the virus. Sofosbuvir, a new class of treatment, has demonstrated in five phase III trials sustained viral response (SVR) rates of over 90% across genotypes, higher than current treatments and has a tolerance profile similar to placebo. The objective was to determine the cost-effectiveness of using sofosbuvir in the treatment of chronic HCV infection. A Markov model was used to compare treatment strategies with and without sofosbuvir. The model simulated the natural history of HCV infection. SVR rates were based on data from clinical trials. Utilities associated with different stages of disease were based on data from the literature. French direct medical costs were used. Price for sofosbuvir was the price used in the early access program for severe fibrosis stages. The incremental cost?effectiveness ratio for sofosbuvir versus current reference treatments was ? 16 278/QALY and varied from 40 000 ?/QALY for F0 stages to 12 080 ?/QALY for F4 stages. The sensitivity analyses carried out confirmed the robustness of this result. Sofosbuvir is a cost-effective treatment option for patients with hepatitis C. äCost-effectiveness of sofosbuvir in the treatment of patients with hep(epmc).pdf DeepDyve Pubget Overpricing