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10.1016/j.molcel.2015.02.021 http://scihub22266oqcxt.onion/10.1016/j.molcel.2015.02.021 C4405354!4405354 !25801171     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25801171 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2015 ; 58 (2 ): 244-54 Nephropedia Template TP {{tp|p=25801171 |t=2015. Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis |pdf=|usr=}}{{25801171 }} gab.com Text Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25801171 #FOAvip Controlled changes in mitochondrial morphology participate in cellular signaling cascades. However, the molecular mechanisms modifying mitochondrial shape are largely unknown. Here we show that the mitogen-activated protein (MAP) kinase cascade member extracellular-signal-regulated kinase (ERK) phosphorylates the pro-fusion protein mitofusin (MFN) 1, modulating its participation in apoptosis and mitochondrial fusion. Phosphoproteomic and biochemical analyses revealed that MFN1 is phosphorylated at an atypical ERK site in its heptad repeat (HR) 1 domain. This site proved essential to mediate MFN1-dependent mitochondrial elongation and apoptosis regulation by the MEK/ERK cascade. A mutant mimicking constitutive MFN1 phosphorylation was less efficient in oligomerizing and mitochondria tethering but bound more avidly to the proapoptotic BCL-2 family member BAK, facilitating its activation and cell death. Moreover, neuronal apoptosis following oxygen glucose deprivation and MEK/ERK activation required an intact MFN1(T562). Our data identify MFN1 as an ERK target to modulate mitochondrial shape and apoptosis. Twit Text FOAVip Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25801171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25801171 #FOAvip English Wikipedia <ref>{{Cite pmid|25801171 }}</ref> Extracellular regulated kinase phosphorylates mitofusin 1 to control mitochondrial morphology and apoptosis #MMPMID25801171 Pyakurel A ; Savoia C ; Hess D ; Scorrano L Mol Cell 2015[Apr]; 58 (2 ): 244-54 PMID25801171 show ga Controlled changes in mitochondrial morphology participate in cellular signaling cascades. However, the molecular mechanisms modifying mitochondrial shape are largely unknown. Here we show that the mitogen-activated protein (MAP) kinase cascade member extracellular-signal-regulated kinase (ERK) phosphorylates the pro-fusion protein mitofusin (MFN) 1, modulating its participation in apoptosis and mitochondrial fusion. Phosphoproteomic and biochemical analyses revealed that MFN1 is phosphorylated at an atypical ERK site in its heptad repeat (HR) 1 domain. This site proved essential to mediate MFN1-dependent mitochondrial elongation and apoptosis regulation by the MEK/ERK cascade. A mutant mimicking constitutive MFN1 phosphorylation was less efficient in oligomerizing and mitochondria tethering but bound more avidly to the proapoptotic BCL-2 family member BAK, facilitating its activation and cell death. Moreover, neuronal apoptosis following oxygen glucose deprivation and MEK/ERK activation required an intact MFN1(T562). Our data identify MFN1 as an ERK target to modulate mitochondrial shape and apoptosis. |*MAP Kinase Signaling System [MESH] |Animals [MESH] |Apoptosis [MESH] |Cells, Cultured [MESH] |Fibroblasts/cytology/metabolism [MESH] |GTP Phosphohydrolases/chemistry/*metabolism [MESH] |Membrane Proteins/chemistry/*metabolism [MESH] |Mice [MESH] |Mitochondria/*physiology [MESH] |Mitochondrial Dynamics [MESH] |Mitochondrial Proteins/chemistry/*metabolism [MESH] |Neurons/cytology/metabolism [MESH] |Oxidative Stress [MESH] |Phosphorylation [MESH] |Proteomics [MESH] |Rats [MESH]Extracellular regulated kinase phosphorylates mitofusin 1 to control (epmc).pdf DeepDyve Pubget Overpricing