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10.1111/imm.12433 http://scihub22266oqcxt.onion/10.1111/imm.12433 C4405333!4405333!25521218     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunology 2015 ; 145 (1): 161-9 Nephropedia Template TP {{tp|p=25521218|t=2015. The atypical MAPK ERK3 controls positive selection of thymocytes |pdf=|usr=}}{{25521218}} gab.com Text The atypical MAPK ERK3 controls positive selection of thymocytes JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=25521218 #FOAvip Extracellular signal-regulated kinase 3 (ERK3 )is an atypical member of the mitogen-activated protein kinase (MAPK) family. We have previously shown that ERK3 is expressed during thymocyte differentiation and that its expression is induced in mature peripheral T cells following activation of ERK1/2 by T-cell receptor (TCR) signalling. Herein, we have investigated whether ERK3 expression is required for proper T-cell selection. Using a knock-in mouse model in which the coding sequence of ERK3 is replaced by the gene encoding for the ?-galactosidase reporter, we show that ERK3 is expressed by double-positive (DP) thymocytes undergoing positive selection. In ERK3-deficient mice with a polyclonal TCR repertoire, we observe a decrease in positive selection. This reduction in positive selection was also observed when ERK3-deficient mice were backcrossed to class I- and class II-restricted TCR transgenic mice. Furthermore, the response of DP thymocytes to in vitro TCR stimulation was strongly reduced in ERK3-deficient mice. Together, these results show that ERK3 expression following TCR signalling is critical for proper thymic positive selection. Twit Text FOAVip The atypical MAPK ERK3 controls positive selection of thymocytes ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=25521218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25521218 #FOAvip English Wikipedia <ref>{{Cite pmid|25521218}}</ref> The atypical MAPK ERK3 controls positive selection of thymocytes #MMPMID25521218 Sirois J; Daudelin JF; Boulet S; Marquis M; Meloche S; Labrecque N Immunology 2015[May]; 145 (1): 161-9 PMID25521218show ga Extracellular signal-regulated kinase 3 (ERK3 )is an atypical member of the mitogen-activated protein kinase (MAPK) family. We have previously shown that ERK3 is expressed during thymocyte differentiation and that its expression is induced in mature peripheral T cells following activation of ERK1/2 by T-cell receptor (TCR) signalling. Herein, we have investigated whether ERK3 expression is required for proper T-cell selection. Using a knock-in mouse model in which the coding sequence of ERK3 is replaced by the gene encoding for the ?-galactosidase reporter, we show that ERK3 is expressed by double-positive (DP) thymocytes undergoing positive selection. In ERK3-deficient mice with a polyclonal TCR repertoire, we observe a decrease in positive selection. This reduction in positive selection was also observed when ERK3-deficient mice were backcrossed to class I- and class II-restricted TCR transgenic mice. Furthermore, the response of DP thymocytes to in vitro TCR stimulation was strongly reduced in ERK3-deficient mice. Together, these results show that ERK3 expression following TCR signalling is critical for proper thymic positive selection. äThe atypical MAPK ERK3 controls positive selection of thymocytes (epmc).pdf DeepDyve Pubget Overpricing