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2015 ; 145
(1
): 1-10
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gab.com Text
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English Wikipedia
Is the developmentally immature immune response in paediatric sepsis a
recapitulation of immune tolerance?
#MMPMID25691226
Maddux AB
; Douglas IS
Immunology
2015[May]; 145
(1
): 1-10
PMID25691226
show ga
Immunologically immature neonates suffer the highest incidence of paediatric
sepsis. Postnatal immunological maturation is characterized by a relatively
hypo-inflammatory immune response. The mechanisms that differentiate the mature
and immature immune responses resemble those that differentiate the hyper- and
hypo-inflammatory responses in severe sepsis. Immunological maturational
differences likely affect the neonate's ability to mount an appropriate
hyper-inflammatory response, a counteractive hypo-inflammatory response, and
subsequent return to immune system homeostasis. To better understand the role of
the hypo-inflammatory response in paediatric sepsis, we will explore the
maturation of the immune system and the effect it may have on the sepsis-induced
hypo-inflammatory response.