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10.1007/s40472-014-0019-4 http://scihub22266oqcxt.onion/10.1007/s40472-014-0019-4 C4405228!4405228!25927019     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Transplant+Rep 2014 ; 1 (3): 166-72 Nephropedia Template TP {{tp|p=25927019|t=2014. T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses?|pdf=|usr=}}{{25927019}} gab.com Text T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses JO: Curr Transplant Rep http://www.kidney.de/pget.php?&tw=1&pmid=25927019 #FOAvip Antibody-mediated, humoral rejection has been recognized as a common cause of transplant dysfunction and is responsible for 30?50 % of failed allografts. The production of antibody is dependent on instructions from memory CD4+ T helper cells that interact with antigen-specific B cells. Recently, a specialized T-cell subset has been identified?T follicular helper (Tfh) cells?which support activated B cells via interleukin (IL)-21 after binding to the IL-21 receptor expressed by these B cells. Therefore, neutralizing the IL-21 pathway will selectively inhibit the allogeneic IL-21-driven Tfh- and B-cell functions. However, little is known of the role of Tfh cells in alloreactivity. In this review, we debate the role of Tfh cells in B-cell-mediated allogeneic responses by discussing their mechanisms of actions. In addition, we speculate about the use of agents that intervene in Tfh?B-cell interaction and consequently prevent or treat antibody-mediated rejection in patients after transplantation. Twit Text FOAVip T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses ????Curr Transplant Rep http://www.kidney.de/pget.php?&tw=1&pmid=25927019 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25927019 #FOAvip English Wikipedia <ref>{{Cite pmid|25927019}}</ref> T Follicular Helper Cells in Transplantation: The Target to Attenuate Antibody-Mediated Allogeneic Responses? #MMPMID25927019 Baan CC; de Graav GN; Boer K Curr Transplant Rep 2014[]; 1 (3): 166-72 PMID25927019show ga Antibody-mediated, humoral rejection has been recognized as a common cause of transplant dysfunction and is responsible for 30?50 % of failed allografts. The production of antibody is dependent on instructions from memory CD4+ T helper cells that interact with antigen-specific B cells. Recently, a specialized T-cell subset has been identified?T follicular helper (Tfh) cells?which support activated B cells via interleukin (IL)-21 after binding to the IL-21 receptor expressed by these B cells. Therefore, neutralizing the IL-21 pathway will selectively inhibit the allogeneic IL-21-driven Tfh- and B-cell functions. However, little is known of the role of Tfh cells in alloreactivity. In this review, we debate the role of Tfh cells in B-cell-mediated allogeneic responses by discussing their mechanisms of actions. In addition, we speculate about the use of agents that intervene in Tfh?B-cell interaction and consequently prevent or treat antibody-mediated rejection in patients after transplantation. äT Follicular Helper Cells in Transplantation: The Target to Attenuate (epmc).pdf DeepDyve Pubget Overpricing