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10.1038/hr.2011.185 http://scihub22266oqcxt.onion/10.1038/hr.2011.185 C4405173!4405173!22170389     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hypertens+Res 2012 ; 35 (3): 318-24 Nephropedia Template TP {{tp|p=22170389|t=2012. Physiological stress increases renal injury in eNOS-knockout mice |pdf=|usr=}}{{22170389}} gab.com Text Physiological stress increases renal injury in eNOS-knockout mice JO: Hypertens Res http://www.kidney.de/pget.php?&tw=1&pmid=22170389 #FOAvip African Americans have a fourfold greater likelihood of developing end-stage renal disease (ESRD) compared with Caucasians. It has been proposed that the increased prevalence may be explained by non-traditional factors such as environmental stress and psychosocial factors. In this study, we used infrequent running to exhaustion as a physiological stressor to mimic real life experiences, such walking up stairs when an elevator is malfunctioning or running to catch a bus, to study its effect on renal injury in a hypertensive mouse model (endothelial nitric oxide synthase-deficient mice; eNOS?/?). This model has previously been shown to have renal injury comparable to that observed in African Americans. The effect of physiological stress on renal injury was examined in the setting of low (0.12%), control (0.45%) and high (8%) dietary salt. Following bouts of physiological stress, eNOS?/? mice had significantly greater interstitial inflammation compared with unstressed eNOS?/? mice (two-way analysis of variance (2-ANOVA), Holm?Sidak; P<0.01). Interestingly, eNOS?/? mice on a high-salt diet had greater interstitial inflammation compared with similarly stressed eNOS?/? mice on a low- or control-salt diet (2-ANOVA, Holm?Sidak; P<0.03). These effects of stress were independent of systolic blood pressure (141 ± 7, 143 ± 4, and 158 ± 8 vs. 141 ± 4, 138 ± 5, 150 ± 4 mm Hg; end of study vs. baseline, respectively). There was no significant effect of stress or dietary salt on renal injury in control wild-type mice (eNOS+/+). These data demonstrate that physiological stress exacerbates the renal injury associated with hypertension and that high-salt compounds this effect of stress. These results provide support for the idea that psychosocial and environmental factors contribute to the increased prevalence of ESRD in hypertensive African Americans. Twit Text FOAVip Physiological stress increases renal injury in eNOS-knockout mice ????Hypertens Res http://www.kidney.de/pget.php?&tw=1&pmid=22170389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22170389 #FOAvip English Wikipedia <ref>{{Cite pmid|22170389}}</ref> Physiological stress increases renal injury in eNOS-knockout mice #MMPMID22170389 Pointer MA; Daumerie G; Bridges L; Yancey S; Howard K; Davis W; Huang P; Loscalzo J Hypertens Res 2012[Mar]; 35 (3): 318-24 PMID22170389show ga African Americans have a fourfold greater likelihood of developing end-stage renal disease (ESRD) compared with Caucasians. It has been proposed that the increased prevalence may be explained by non-traditional factors such as environmental stress and psychosocial factors. In this study, we used infrequent running to exhaustion as a physiological stressor to mimic real life experiences, such walking up stairs when an elevator is malfunctioning or running to catch a bus, to study its effect on renal injury in a hypertensive mouse model (endothelial nitric oxide synthase-deficient mice; eNOS?/?). This model has previously been shown to have renal injury comparable to that observed in African Americans. The effect of physiological stress on renal injury was examined in the setting of low (0.12%), control (0.45%) and high (8%) dietary salt. Following bouts of physiological stress, eNOS?/? mice had significantly greater interstitial inflammation compared with unstressed eNOS?/? mice (two-way analysis of variance (2-ANOVA), Holm?Sidak; P<0.01). Interestingly, eNOS?/? mice on a high-salt diet had greater interstitial inflammation compared with similarly stressed eNOS?/? mice on a low- or control-salt diet (2-ANOVA, Holm?Sidak; P<0.03). These effects of stress were independent of systolic blood pressure (141 ± 7, 143 ± 4, and 158 ± 8 vs. 141 ± 4, 138 ± 5, 150 ± 4 mm Hg; end of study vs. baseline, respectively). There was no significant effect of stress or dietary salt on renal injury in control wild-type mice (eNOS+/+). These data demonstrate that physiological stress exacerbates the renal injury associated with hypertension and that high-salt compounds this effect of stress. These results provide support for the idea that psychosocial and environmental factors contribute to the increased prevalence of ESRD in hypertensive African Americans. äPhysiological stress increases renal injury in eNOS-knockout mice (epmc).pdf DeepDyve Pubget Overpricing