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10.1002/eji.201445108 http://scihub22266oqcxt.onion/10.1002/eji.201445108 C4405047!4405047 !25615828     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25615828 &cmd=llinks): Failed to open stream: HTTP request failed! 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Thymus medulla fosters generation of natural Treg cells, invariant ?? T cells, and invariant NKT cells: what we learn from intrathymic migration |pdf=|usr=}}{{25615828 }} gab.com Text Thymus medulla fosters generation of natural Treg cells, invariant T cells, and invariant NKT cells: what we learn from intrathymic migration JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25615828 #FOAvip The organization of the thymus into distinct cortical and medullary regions enables it to control the step-wise migration and development of immature T-cell precursors. Such a process provides access to specialized cortical and medullary thymic epithelial cells at defined stages of maturation, ensuring the generation of self-tolerant and MHC-restricted conventional CD4(+) and CD8(+) ?? T cells. The migratory cues and stromal cell requirements that regulate the development of conventional ?? T cells have been well studied. However, the thymus also fosters the generation of several immunoregulatory T-cell populations that form key components of both innate and adaptive immune responses. These include Foxp3(+) natural regulatory T cells, invariant ?? T cells, and CD1d-restricted invariant natural killer T cells (iNKT cells). While less is known about the intrathymic requirements of these nonconventional T cells, recent studies have highlighted the importance of the thymus medulla in their development. Here, we review recent findings on the mechanisms controlling the intrathymic migration of distinct T-cell subsets, and relate this to knowledge of the microenvironmental requirements of these cells. Twit Text FOAVip Thymus medulla fosters generation of natural Treg cells, invariant T cells, and invariant NKT cells: what we learn from intrathymic migration ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25615828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25615828 #FOAvip English Wikipedia <ref>{{Cite pmid|25615828 }}</ref> Thymus medulla fosters generation of natural Treg cells, invariant ?? T cells, and invariant NKT cells: what we learn from intrathymic migration #MMPMID25615828 Cowan JE ; Jenkinson WE ; Anderson G Eur J Immunol 2015[Mar]; 45 (3 ): 652-60 PMID25615828 show ga The organization of the thymus into distinct cortical and medullary regions enables it to control the step-wise migration and development of immature T-cell precursors. Such a process provides access to specialized cortical and medullary thymic epithelial cells at defined stages of maturation, ensuring the generation of self-tolerant and MHC-restricted conventional CD4(+) and CD8(+) ?? T cells. The migratory cues and stromal cell requirements that regulate the development of conventional ?? T cells have been well studied. However, the thymus also fosters the generation of several immunoregulatory T-cell populations that form key components of both innate and adaptive immune responses. These include Foxp3(+) natural regulatory T cells, invariant ?? T cells, and CD1d-restricted invariant natural killer T cells (iNKT cells). While less is known about the intrathymic requirements of these nonconventional T cells, recent studies have highlighted the importance of the thymus medulla in their development. Here, we review recent findings on the mechanisms controlling the intrathymic migration of distinct T-cell subsets, and relate this to knowledge of the microenvironmental requirements of these cells. |Animals [MESH] |CD8-Positive T-Lymphocytes/cytology/immunology [MESH] |Cell Movement/*immunology [MESH] |Humans [MESH] |Natural Killer T-Cells/cytology/*immunology [MESH] |Receptors, Antigen, T-Cell, alpha-beta/immunology [MESH] |Receptors, Antigen, T-Cell, gamma-delta/*immunology [MESH] |T-Lymphocytes, Regulatory/cytology/*immunology [MESH]Thymus medulla fosters generation of natural Treg cells, invariant ?? (epmc).pdf DeepDyve Pubget Overpricing