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2015 ; 37
(4
): 426-35
Nephropedia Template TP
gab.com Text
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English Wikipedia
Uptake of extracellular DNA: competence induced pili in natural transformation of
Streptococcus pneumoniae
#MMPMID25640084
Muschiol S
; Balaban M
; Normark S
; Henriques-Normark B
Bioessays
2015[Apr]; 37
(4
): 426-35
PMID25640084
show ga
Transport of DNA across bacterial membranes involves complex DNA uptake systems.
In Gram-positive bacteria, the DNA uptake machinery shares fundamental
similarities with type IV pili and type II secretion systems. Although dedicated
pilus structures, such as type IV pili in Gram-negative bacteria, are necessary
for efficient DNA uptake, the role of similar structures in Gram-positive
bacteria is just beginning to emerge. Recently two essentially very different
pilus structures composed of the same major pilin protein ComGC were proposed to
be involved in transformation of the Gram-positive bacterium Streptococcus
pneumoniae - one is a long, thin, type IV pilus-like fiber with DNA binding
capacity and the other one is a pilus structure that was thicker, much shorter
and not able to bind DNA. Here we discuss how competence induced pili, either by
pilus retraction or by a transient pilus-related opening in the cell wall, may
mediate DNA uptake in S. pneumoniae.