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10.4161/2162402X.2014.985951

http://scihub22266oqcxt.onion/10.4161/2162402X.2014.985951
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C4404821!4404821!25949883
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suck abstract from ncbi


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pmid25949883      Oncoimmunology 2015 ; 4 (2): ä
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  • HIF-2?/ITPR1 axis: A new saboteur of NK-mediated lysis #MMPMID25949883
  • Messai Y; Noman MZ; Hasmim M; Escudier B; Chouaib S
  • Oncoimmunology 2015[Feb]; 4 (2): ä PMID25949883show ga
  • We recently investigated the role of von Hippel-Lindau (VHL) mutation and the subsequent induction of hypoxia-inducible factor 2? (HIF-2?) in the regulation of renal cell carcinoma (RCC) susceptibility to natural killer (NK) cell-mediated killing. We demonstrated that the resistance of VHL-mutated RCC cell line 786-0 to NK-mediated lysis requires HIF-2? and ITPR1, a direct novel target of HIF-2?, through the activation of autophagy in target cells by NK-derived signals.
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