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Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Oncoimmunology 2015 ; 4 (2): ä Nephropedia Template TP
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A novel subset of B7-H3+CD14+HLA-DR?/low myeloid-derived suppressor cells are associated with progression of human NSCLC #MMPMID25949876
Zhang G; Huang H; Zhu Y; Yu G; Gao X; Xu Y; Liu C; Hou J; Zhang X
Oncoimmunology 2015[Feb]; 4 (2): ä PMID25949876show ga
Myeloid-derived suppressor cells (MDSC) potently inhibit antitumor immune responses, and thereby promoti tumor progression and metastasis. However, the nature of human tumor-infiltrating MDSC remains poorly characterized. Here, we find B7-H3 is exclusively expressed on a subset of intratumoral CD14+HLA-DR?/low MDSC but absent from adjacent normal lung tissues of patients with non-small cell lung carcinoma (NSCLC). Cytokine analysis revealed that B7-H3+CD14+HLA-DR?/low MDSC (B7-H3+MDSC) produced higher levels of IL-10 and TNF? but lower levels of IL-1? and IL-6 when compared with B7-H3?CD14+HLA-DR?/low myeloid-derived suppressor cells (B7-H3?MDSC). In a murine lung cancer model, B7-H3+MDSCs were found only in the tumor microenvironment and their frequencies increased during tumor progression. Clinical data analysis indicated that a higher frequency of B7-H3+MDSCs was associated with reduced recurrence-free survival in patients with NSCLC. Taken together, we identify a novel subset of MDSCs within the tumor microenvironment that fosters tumor progression.