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10.4161/2162402X.2014.977164 http://scihub22266oqcxt.onion/10.4161/2162402X.2014.977164 C4404793!4404793 !25949876     free     free     free       Oncoimmunology 2015 ; 4 (2 ): e977164 Nephropedia Template TP {{tp|p=25949876 |t=2015. A novel subset of B7-H3(+)CD14(+)HLA-DR(-/low) myeloid-derived suppressor cells are associated with progression of human NSCLC |pdf=|usr=}}{{25949876 }} gab.com Text A novel subset of B7-H3(+)CD14(+)HLA-DR(-/low) myeloid-derived suppressor cells are associated with progression of human NSCLC JO: Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=25949876 #FOAvip Myeloid-derived suppressor cells (MDSC) potently inhibit antitumor immune responses, and thereby promoti tumor progression and metastasis. However, the nature of human tumor-infiltrating MDSC remains poorly characterized. Here, we find B7-H3 is exclusively expressed on a subset of intratumoral CD14(+)HLA-DR(-/low) MDSC but absent from adjacent normal lung tissues of patients with non-small cell lung carcinoma (NSCLC). Cytokine analysis revealed that B7-H3(+)CD14(+)HLA-DR(-/low) MDSC (B7-H3(+)MDSC) produced higher levels of IL-10 and TNF? but lower levels of IL-1? and IL-6 when compared with B7-H3(-)CD14(+)HLA-DR(-/low) myeloid-derived suppressor cells (B7-H3(-)MDSC). In a murine lung cancer model, B7-H3(+)MDSCs were found only in the tumor microenvironment and their frequencies increased during tumor progression. Clinical data analysis indicated that a higher frequency of B7-H3(+)MDSCs was associated with reduced recurrence-free survival in patients with NSCLC. Taken together, we identify a novel subset of MDSCs within the tumor microenvironment that fosters tumor progression. Twit Text FOAVip A novel subset of B7-H3(+)CD14(+)HLA-DR(-/low) myeloid-derived suppressor cells are associated with progression of human NSCLC ????Oncoimmunology http://www.kidney.de/pget.php?&tw=1&pmid=25949876 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25949876 #FOAvip English Wikipedia <ref>{{Cite pmid|25949876 }}</ref> A novel subset of B7-H3(+)CD14(+)HLA-DR(-/low) myeloid-derived suppressor cells are associated with progression of human NSCLC #MMPMID25949876 Zhang G ; Huang H ; Zhu Y ; Yu G ; Gao X ; Xu Y ; Liu C ; Hou J ; Zhang X Oncoimmunology 2015[Feb]; 4 (2 ): e977164 PMID25949876 show ga Myeloid-derived suppressor cells (MDSC) potently inhibit antitumor immune responses, and thereby promoti tumor progression and metastasis. However, the nature of human tumor-infiltrating MDSC remains poorly characterized. Here, we find B7-H3 is exclusively expressed on a subset of intratumoral CD14(+)HLA-DR(-/low) MDSC but absent from adjacent normal lung tissues of patients with non-small cell lung carcinoma (NSCLC). Cytokine analysis revealed that B7-H3(+)CD14(+)HLA-DR(-/low) MDSC (B7-H3(+)MDSC) produced higher levels of IL-10 and TNF? but lower levels of IL-1? and IL-6 when compared with B7-H3(-)CD14(+)HLA-DR(-/low) myeloid-derived suppressor cells (B7-H3(-)MDSC). In a murine lung cancer model, B7-H3(+)MDSCs were found only in the tumor microenvironment and their frequencies increased during tumor progression. Clinical data analysis indicated that a higher frequency of B7-H3(+)MDSCs was associated with reduced recurrence-free survival in patients with NSCLC. Taken together, we identify a novel subset of MDSCs within the tumor microenvironment that fosters tumor progression. ?A novel subset of B7-H3(+)CD14(+)HLA-DR(-/low) myeloid-derived suppres(epmc).pdf DeepDyve Pubget Overpricing