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10.1186/s12868-015-0160-8 http://scihub22266oqcxt.onion/10.1186/s12868-015-0160-8 C4404690!4404690!25881110     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Neurosci 2015 ; 16 (ä): ä Nephropedia Template TP {{tp|p=25881110|t=2015. Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts |pdf=|usr=}}{{25881110}} gab.com Text Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts JO: BMC Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25881110 #FOAvip Background: Recovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the recovery of functional deficits after stroke though the nature and origin of these cells remains unclear. Results: In the present study, we aimed to characterize the population of DCX+ cells in the vicinity of ischemic infarcts in a mouse model in detail. Employing a photothrombosis model, distinct immunohistochemical techniques, stereology and confocal microscopy, we show that: i) DCX+ cells in the perilesional zone do not constitute a homogenous population and two cell types, stellate and polar cells can be distinguished according to their morphology. ii) Stellate cells are mainly located in the lateral and medial vicinity of the insult and express astrocytic markers. iii) Polar cells are found almost exclusively in the corpus callosum region including in the preserved deep cortical layers close to the subventricular zone (SVZ). Further, they do not show any colocalisation of glial markers. Polar morphology and distribution suggest a migration towards the lesion. Conclusions: In summary, our findings provide evidence that in mice DCX+ cells in the perilesional zone of cortical infarcts comprise a distinct cell population and the majority of cells are of glial nature. Electronic supplementary material: The online version of this article (doi:10.1186/s12868-015-0160-8) contains supplementary material, which is available to authorized users. Twit Text FOAVip Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts ????BMC Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25881110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25881110 #FOAvip English Wikipedia <ref>{{Cite pmid|25881110}}</ref> Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts #MMPMID25881110 Kunze A; Achilles A; Keiner S; Witte OW; Redecker C BMC Neurosci 2015[]; 16 (ä): ä PMID25881110show ga Background: Recovery following stroke depends on cellular plasticity in the perilesional zone (PZ). Doublecortin (DCX), a protein mainly labeling immature neurons in neurogenic niches is also highly expressed in the vicinity of focal cortical infarcts. Notably, the number of DCX+ cells positively correlates with the recovery of functional deficits after stroke though the nature and origin of these cells remains unclear. Results: In the present study, we aimed to characterize the population of DCX+ cells in the vicinity of ischemic infarcts in a mouse model in detail. Employing a photothrombosis model, distinct immunohistochemical techniques, stereology and confocal microscopy, we show that: i) DCX+ cells in the perilesional zone do not constitute a homogenous population and two cell types, stellate and polar cells can be distinguished according to their morphology. ii) Stellate cells are mainly located in the lateral and medial vicinity of the insult and express astrocytic markers. iii) Polar cells are found almost exclusively in the corpus callosum region including in the preserved deep cortical layers close to the subventricular zone (SVZ). Further, they do not show any colocalisation of glial markers. Polar morphology and distribution suggest a migration towards the lesion. Conclusions: In summary, our findings provide evidence that in mice DCX+ cells in the perilesional zone of cortical infarcts comprise a distinct cell population and the majority of cells are of glial nature. Electronic supplementary material: The online version of this article (doi:10.1186/s12868-015-0160-8) contains supplementary material, which is available to authorized users. äTwo distinct populations of doublecortin-positive cells in the periles(epmc).pdf DeepDyve Pubget Overpricing