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10.1186/s13054-015-0888-7 http://scihub22266oqcxt.onion/10.1186/s13054-015-0888-7 C4404291!4404291 !25879776     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25879776 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Crit+Care 2015 ; 19 (1 ): 167 Nephropedia Template TP {{tp|p=25879776 |t=2015. Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis |pdf=|usr=}}{{25879776 }} gab.com Text Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis JO: Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=25879776 #FOAvip INTRODUCTION: Intravenous fish oil (FO) lipid emulsions (LEs) are rich in ?-3 polyunsaturated fatty acids, which exhibit anti-inflammatory and immunomodulatory effects. We previously demonstrated that FO-containing LEs may be able to decrease mortality and ventilation days in patients who are critically ill. Since 2014, several additional randomized controlled trials (RCTs) of FO-containing LEs have been published. Therefore, the purpose of this systematic review was to update our previous systematic review with the aim of elucidating the efficacy of FO-containing LEs on clinical outcomes of patients who are critically ill. METHODS: We searched electronic databases from 1980 to 2014. We included four new RCTs conducted in critically ill adult patients in which researchers evaluated FO-containing LEs in parenterally or enterally fed patients. RESULTS: A total of 10 RCTs (n =?733) met inclusion criteria. The mean methodological score was 8 (range, 3 to 12). No effect on overall mortality was found. When we aggregated the results of five RCTs in which infections were reported, we found that FO-containing LEs significantly reduced infections (risk ratio (RR) =?0.64; 95% confidence interval (CI), 0.44 to 0.92; P =?0.02; heterogeneity I (2) =?0%). Subgroup analysis demonstrated that predominantly enteral nutrition-based trials showed a tendency toward a reduction in mortality (RR =?0.69; 95% CI, 0.40 to 1.18; P =0.18; heterogeneity I (2) =35%). High-quality trials showed a significant reduction in hospital length of stay (LOS) (weighted mean difference = -7.42; 95% CI, -11.89 to -2.94; P =?0.001), whereas low-quality trials had no effect (P =?0.45). The results of the test for subgroup differences in hospital LOS was significant (P =?0.001). CONCLUSION: FO-containing LEs may be associated with a reduction in infections and also could be associated with a reduction in duration of ventilation and hospital LOS. Further large-scale RCTs are warranted and should be aimed at consolidating potential positive treatment effects. Twit Text FOAVip Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis ????Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=25879776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25879776 #FOAvip English Wikipedia <ref>{{Cite pmid|25879776 }}</ref> Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis #MMPMID25879776 Manzanares W ; Langlois PL ; Dhaliwal R ; Lemieux M ; Heyland DK Crit Care 2015[Apr]; 19 (1 ): 167 PMID25879776 show ga INTRODUCTION: Intravenous fish oil (FO) lipid emulsions (LEs) are rich in ?-3 polyunsaturated fatty acids, which exhibit anti-inflammatory and immunomodulatory effects. We previously demonstrated that FO-containing LEs may be able to decrease mortality and ventilation days in patients who are critically ill. Since 2014, several additional randomized controlled trials (RCTs) of FO-containing LEs have been published. Therefore, the purpose of this systematic review was to update our previous systematic review with the aim of elucidating the efficacy of FO-containing LEs on clinical outcomes of patients who are critically ill. METHODS: We searched electronic databases from 1980 to 2014. We included four new RCTs conducted in critically ill adult patients in which researchers evaluated FO-containing LEs in parenterally or enterally fed patients. RESULTS: A total of 10 RCTs (n =?733) met inclusion criteria. The mean methodological score was 8 (range, 3 to 12). No effect on overall mortality was found. When we aggregated the results of five RCTs in which infections were reported, we found that FO-containing LEs significantly reduced infections (risk ratio (RR) =?0.64; 95% confidence interval (CI), 0.44 to 0.92; P =?0.02; heterogeneity I (2) =?0%). Subgroup analysis demonstrated that predominantly enteral nutrition-based trials showed a tendency toward a reduction in mortality (RR =?0.69; 95% CI, 0.40 to 1.18; P =0.18; heterogeneity I (2) =35%). High-quality trials showed a significant reduction in hospital length of stay (LOS) (weighted mean difference = -7.42; 95% CI, -11.89 to -2.94; P =?0.001), whereas low-quality trials had no effect (P =?0.45). The results of the test for subgroup differences in hospital LOS was significant (P =?0.001). CONCLUSION: FO-containing LEs may be associated with a reduction in infections and also could be associated with a reduction in duration of ventilation and hospital LOS. Further large-scale RCTs are warranted and should be aimed at consolidating potential positive treatment effects. |Critical Illness/mortality/*therapy [MESH] |Fat Emulsions, Intravenous/*therapeutic use [MESH] |Fish Oils/adverse effects/*therapeutic use [MESH] |Humans [MESH] |Intensive Care Units [MESH] |Length of Stay [MESH]Intravenous fish oil lipid emulsions in critically ill patients: an up(epmc).pdf DeepDyve Pubget Overpricing