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10.1186/s13069-015-0024-y http://scihub22266oqcxt.onion/10.1186/s13069-015-0024-y C4404279!4404279!25901180     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Fibrogenesis+Tissue+Repair 2015 ; 8 (ä): ä Nephropedia Template TP {{tp|p=25901180|t=2015. Primary cilia modulate balance of canonical and non-canonical Wnt signaling responses in the injured kidney |pdf=|usr=}}{{25901180}} gab.com Text Primary cilia modulate balance of canonical and non-canonical Wnt signaling responses in the injured kidney JO: Fibrogenesis Tissue Repair http://www.kidney.de/pget.php?&tw=1&pmid=25901180 #FOAvip Background: While kidney injury is associated with re-expression of numerous Wnt ligands and receptors, molecular mechanisms which underlie regulation of distinct Wnt signaling pathways and ensuing biological consequences remain incompletely understood. Primary cilia are increasingly being recognized as cellular ?antennae? which sense and transduce signals from the microenvironment, particularly through Wnt signaling. Here, we explored the role of cilia as modulators of canonical and non-canonical Wnt signaling activities involving tubular epithelial cells in the injured kidney. Results: We demonstrate that in the mouse model of unilateral ureter obstruction, progression of kidney injury correlates with increased expression of numerous Wnt ligands, and that increased expression of Wnt ligands corresponded with over-activation of canonical Wnt signaling. In contrast, non-canonical Wnt signaling dropped significantly during the course of kidney injury despite gradually increased expression of typical non-canonical and intermediate Wnt signaling ligands. We further demonstrate that in cultured tubular epithelial cells, cilia modulate balance between canonical and non-canonical signaling responses upon exposure to Wnt ligands. Conclusions: We provide evidence that in the context of renal injury, primary cilia act as molecular switches between canonical and non-canonical Wnt signaling activity, possibly determining between regenerative and pro-fibrotic effects of Wnt re-expression in the injured kidney. Electronic supplementary material: The online version of this article (doi:10.1186/s13069-015-0024-y) contains supplementary material, which is available to authorized users. Twit Text FOAVip Primary cilia modulate balance of canonical and non-canonical Wnt signaling responses in the injured kidney ????Fibrogenesis Tissue Repair http://www.kidney.de/pget.php?&tw=1&pmid=25901180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25901180 #FOAvip English Wikipedia <ref>{{Cite pmid|25901180}}</ref> Primary cilia modulate balance of canonical and non-canonical Wnt signaling responses in the injured kidney #MMPMID25901180 Saito S; Tampe B; Müller GA; Zeisberg M Fibrogenesis Tissue Repair 2015[]; 8 (ä): ä PMID25901180show ga Background: While kidney injury is associated with re-expression of numerous Wnt ligands and receptors, molecular mechanisms which underlie regulation of distinct Wnt signaling pathways and ensuing biological consequences remain incompletely understood. Primary cilia are increasingly being recognized as cellular ?antennae? which sense and transduce signals from the microenvironment, particularly through Wnt signaling. Here, we explored the role of cilia as modulators of canonical and non-canonical Wnt signaling activities involving tubular epithelial cells in the injured kidney. Results: We demonstrate that in the mouse model of unilateral ureter obstruction, progression of kidney injury correlates with increased expression of numerous Wnt ligands, and that increased expression of Wnt ligands corresponded with over-activation of canonical Wnt signaling. In contrast, non-canonical Wnt signaling dropped significantly during the course of kidney injury despite gradually increased expression of typical non-canonical and intermediate Wnt signaling ligands. We further demonstrate that in cultured tubular epithelial cells, cilia modulate balance between canonical and non-canonical signaling responses upon exposure to Wnt ligands. Conclusions: We provide evidence that in the context of renal injury, primary cilia act as molecular switches between canonical and non-canonical Wnt signaling activity, possibly determining between regenerative and pro-fibrotic effects of Wnt re-expression in the injured kidney. Electronic supplementary material: The online version of this article (doi:10.1186/s13069-015-0024-y) contains supplementary material, which is available to authorized users. äPrimary cilia modulate balance of canonical and non-canonical Wnt sign(epmc).pdf DeepDyve Pubget Overpricing