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10.1186/s12943-015-0332-2 http://scihub22266oqcxt.onion/10.1186/s12943-015-0332-2 C4404090!4404090!25888829     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cancer 2015 ; 14 (ä): ä Nephropedia Template TP {{tp|p=25888829|t=2015. PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-?B/MMP-9 signaling pathway |pdf=|usr=}}{{25888829}} gab.com Text PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF- B/MMP-9 signaling pathway JO: Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25888829 #FOAvip Background: PinX1 (PIN2/TRF1-interacting telomerase inhibitor 1) was suggested to be correlated with tumor progression. This study was designed to evaluate the role of PinX1 in human breast cancer. Methods: To evaluate the function of PinX1 in breast cancer, we used a tissue microarray (TMA) of 405 human breast cancer patients and immunohistochemistry to analyze the correlation between PinX1 expression and clinicopathologic variables and patient survival. We also detected the abilities of cell migration and invasion in breast cancer by performing cell migration and invasion assay, gelatin zymography and western blot analysis. Lastly, we set up the nude mice model by Tail vein assay to exam the functional role of PinX1 in breast cancer metastasis. Results: We found that low PinX1 expression was associated with lymph node metastasis (P?=?0.002) and histology grade (P?=?0.001) in patients, as well as with poorer overall and disease-specific survival (P?=?0.010 and P?=?0.003, respectively). Moreover, we identified that PinX1 inhibited the migration and invasion of breast cancer by suppressing MMP-9 expression and activity via NF-?B-dependent transcription in vitro. Finally, our mice model confirmed that PinX1 suppressed breast cancer metastasis in vivo. Conclusions: Our data revealed that low PinX1 expression was an independent negative prognostic factor for breast cancer patients. These findings suggested that PinX1 might be function as a tumor metastasis suppressor in the development and progression of breast cancer by regulating the NF-?B/MMP-9 signaling pathway, and might be a prognostic marker as well as a therapeutic target for breast cancer. Electronic supplementary material: The online version of this article (doi:10.1186/s12943-015-0332-2) contains supplementary material, which is available to authorized users. Twit Text FOAVip PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF- B/MMP-9 signaling pathway ????Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25888829 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25888829 #FOAvip English Wikipedia <ref>{{Cite pmid|25888829}}</ref> PinX1 inhibits the invasion and metastasis of human breast cancer via suppressing NF-?B/MMP-9 signaling pathway #MMPMID25888829 Shi M; Cao M; Song J; Liu Q; Li H; Meng F; Pan Z; Bai J; Zheng J Mol Cancer 2015[]; 14 (ä): ä PMID25888829show ga Background: PinX1 (PIN2/TRF1-interacting telomerase inhibitor 1) was suggested to be correlated with tumor progression. This study was designed to evaluate the role of PinX1 in human breast cancer. Methods: To evaluate the function of PinX1 in breast cancer, we used a tissue microarray (TMA) of 405 human breast cancer patients and immunohistochemistry to analyze the correlation between PinX1 expression and clinicopathologic variables and patient survival. We also detected the abilities of cell migration and invasion in breast cancer by performing cell migration and invasion assay, gelatin zymography and western blot analysis. Lastly, we set up the nude mice model by Tail vein assay to exam the functional role of PinX1 in breast cancer metastasis. Results: We found that low PinX1 expression was associated with lymph node metastasis (P?=?0.002) and histology grade (P?=?0.001) in patients, as well as with poorer overall and disease-specific survival (P?=?0.010 and P?=?0.003, respectively). Moreover, we identified that PinX1 inhibited the migration and invasion of breast cancer by suppressing MMP-9 expression and activity via NF-?B-dependent transcription in vitro. Finally, our mice model confirmed that PinX1 suppressed breast cancer metastasis in vivo. Conclusions: Our data revealed that low PinX1 expression was an independent negative prognostic factor for breast cancer patients. These findings suggested that PinX1 might be function as a tumor metastasis suppressor in the development and progression of breast cancer by regulating the NF-?B/MMP-9 signaling pathway, and might be a prognostic marker as well as a therapeutic target for breast cancer. Electronic supplementary material: The online version of this article (doi:10.1186/s12943-015-0332-2) contains supplementary material, which is available to authorized users. äPinX1 inhibits the invasion and metastasis of human breast cancer via (epmc).pdf DeepDyve Pubget Overpricing