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10.1002/ana.24367 http://scihub22266oqcxt.onion/10.1002/ana.24367 C4403966!4403966!25623048     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Neurol 2015 ; 77 (4): 571-81 Nephropedia Template TP {{tp|p=25623048|t=2015. Prediction of brain age suggests accelerated atrophy after traumatic brain injury |pdf=|usr=}}{{25623048}} gab.com Text Prediction of brain age suggests accelerated atrophy after traumatic brain injury JO: Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25623048 #FOAvip Objective: The long-term effects of traumatic brain injury (TBI) can resemble observed in normal ageing, suggesting that TBI may accelerate the ageing process. We investigate this using a neuroimaging model that predicts brain age in healthy individuals and then apply it to TBI patients. We define individuals' differences in chronological and predicted structural "brain age," and test whether TBI produces progressive atrophy and how this relates to cognitive function. Methods: A predictive model of normal ageing was defined using machine learning in 1,537 healthy individuals, based on magnetic resonance imaging?derived estimates of gray matter (GM) and white matter (WM). This ageing model was then applied to test 99 TBI patients and 113 healthy controls to estimate brain age. Results: The initial model accurately predicted age in healthy individuals (r?*?0.92). TBI brains were estimated to be "older," with a mean predicted age difference (PAD) between chronological and estimated brain age of 4.66 years (±10.8) for GM and 5.97 years (±11.22) for WM. This PAD predicted cognitive impairment and correlated strongly with the time since TBI, indicating that brain tissue loss increases throughout the chronic postinjury phase. Interpretation: TBI patients' brains were estimated to be older than their chronological age. This discrepancy increases with time since injury, suggesting that TBI accelerates the rate of brain atrophy. This may be an important factor in the increased susceptibility in TBI patients for dementia and other age-associated conditions, motivating further research into the age-like effects of brain injury and other neurological diseases. Twit Text FOAVip Prediction of brain age suggests accelerated atrophy after traumatic brain injury ????Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25623048 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25623048 #FOAvip English Wikipedia <ref>{{Cite pmid|25623048}}</ref> Prediction of brain age suggests accelerated atrophy after traumatic brain injury #MMPMID25623048 Cole JH; Leech R; Sharp DJ Ann Neurol 2015[Apr]; 77 (4): 571-81 PMID25623048show ga Objective: The long-term effects of traumatic brain injury (TBI) can resemble observed in normal ageing, suggesting that TBI may accelerate the ageing process. We investigate this using a neuroimaging model that predicts brain age in healthy individuals and then apply it to TBI patients. We define individuals' differences in chronological and predicted structural "brain age," and test whether TBI produces progressive atrophy and how this relates to cognitive function. Methods: A predictive model of normal ageing was defined using machine learning in 1,537 healthy individuals, based on magnetic resonance imaging?derived estimates of gray matter (GM) and white matter (WM). This ageing model was then applied to test 99 TBI patients and 113 healthy controls to estimate brain age. Results: The initial model accurately predicted age in healthy individuals (r?*?0.92). TBI brains were estimated to be "older," with a mean predicted age difference (PAD) between chronological and estimated brain age of 4.66 years (±10.8) for GM and 5.97 years (±11.22) for WM. This PAD predicted cognitive impairment and correlated strongly with the time since TBI, indicating that brain tissue loss increases throughout the chronic postinjury phase. Interpretation: TBI patients' brains were estimated to be older than their chronological age. This discrepancy increases with time since injury, suggesting that TBI accelerates the rate of brain atrophy. This may be an important factor in the increased susceptibility in TBI patients for dementia and other age-associated conditions, motivating further research into the age-like effects of brain injury and other neurological diseases. äPrediction of brain age suggests accelerated atrophy after traumatic b(epmc).pdf DeepDyve Pubget Overpricing