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10.1073/pnas.1418088112 http://scihub22266oqcxt.onion/10.1073/pnas.1418088112 C4403184!4403184 !25825736     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25825736 &cmd=llinks): Failed to open stream: HTTP request failed! 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Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy |pdf=|usr=}}{{25825736 }} gab.com Text Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25825736 #FOAvip Sphingomyelin (SM) and cholesterol (chol)-rich domains in cell membranes, called lipid rafts, are thought to have important biological functions related to membrane signaling and protein trafficking. To visualize the distribution of SM in lipid rafts by means of Raman microscopy, we designed and synthesized an SM analog tagged with a Raman-active diyne moiety (diyne-SM). Diyne-SM showed a strong peak in a Raman silent region that is free of interference from intrinsic vibrational modes of lipids and did not appear to alter the properties of SM-containing monolayers. Therefore, we used Raman microscopy to directly visualize the distribution of diyne-SM in raft-mimicking domains formed in SM/dioleoylphosphatidylcholine/chol ternary monolayers. Raman images visualized a heterogeneous distribution of diyne-SM, which showed marked variation, even within a single ordered domain. Specifically, diyne-SM was enriched in the central area of raft domains compared with the peripheral area. These results seem incompatible with the generally accepted raft model, in which the raft and nonraft phases show a clear biphasic separation. One of the possible reasons is that gradual changes of SM concentration occur between SM-rich and -poor regions to minimize hydrophobic mismatch. We believe that our technique of hyperspectral Raman imaging of a single lipid monolayer opens the door to quantitative analysis of lipid membranes by providing both chemical information and spatial distribution with high (diffraction-limited) spatial resolution. Twit Text FOAVip Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25825736 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25825736 #FOAvip English Wikipedia <ref>{{Cite pmid|25825736 }}</ref> Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy #MMPMID25825736 Ando J ; Kinoshita M ; Cui J ; Yamakoshi H ; Dodo K ; Fujita K ; Murata M ; Sodeoka M Proc Natl Acad Sci U S A 2015[Apr]; 112 (15 ): 4558-63 PMID25825736 show ga Sphingomyelin (SM) and cholesterol (chol)-rich domains in cell membranes, called lipid rafts, are thought to have important biological functions related to membrane signaling and protein trafficking. To visualize the distribution of SM in lipid rafts by means of Raman microscopy, we designed and synthesized an SM analog tagged with a Raman-active diyne moiety (diyne-SM). Diyne-SM showed a strong peak in a Raman silent region that is free of interference from intrinsic vibrational modes of lipids and did not appear to alter the properties of SM-containing monolayers. Therefore, we used Raman microscopy to directly visualize the distribution of diyne-SM in raft-mimicking domains formed in SM/dioleoylphosphatidylcholine/chol ternary monolayers. Raman images visualized a heterogeneous distribution of diyne-SM, which showed marked variation, even within a single ordered domain. Specifically, diyne-SM was enriched in the central area of raft domains compared with the peripheral area. These results seem incompatible with the generally accepted raft model, in which the raft and nonraft phases show a clear biphasic separation. One of the possible reasons is that gradual changes of SM concentration occur between SM-rich and -poor regions to minimize hydrophobic mismatch. We believe that our technique of hyperspectral Raman imaging of a single lipid monolayer opens the door to quantitative analysis of lipid membranes by providing both chemical information and spatial distribution with high (diffraction-limited) spatial resolution. |*Membranes, Artificial [MESH] |Cholesterol/chemistry/metabolism [MESH] |Membrane Microdomains/*metabolism [MESH] |Microscopy, Confocal/*methods [MESH] |Molecular Structure [MESH] |Phosphatidylcholines/chemistry/metabolism [MESH] |Reproducibility of Results [MESH] |Spectrum Analysis, Raman/*methods [MESH] |Sphingomyelins/chemistry/*metabolism [MESH]Sphingomyelin distribution in lipid rafts of artificial monolayer memb(epmc).pdf DeepDyve Pubget Overpricing