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10.1073/pnas.1502855112 http://scihub22266oqcxt.onion/10.1073/pnas.1502855112 C4403148!4403148!25825768     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (15): 4666-71 Nephropedia Template TP {{tp|p=25825768|t=2015. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells |pdf=|usr=}}{{25825768}} gab.com Text Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25825768 #FOAvip Maintenance and reprogramming of pluripotency are among the most important issues in stem cell biology and regenerative medicine. Pluripotency is governed by several key transcription factors regulating transcription of other factors. Among these, regulation of OCT4 transcription by NANOG (from Irish myth-ology Tír na nÓg) is a critical interaction. We present here the crystal structure of human NANOG homeodomain in complex with the OCT4 promoter DNA and, through a series of ration-ally designed mutations, we identify key functional residues in the protein?DNA interaction, protein stability, and maintenance of mouse ESC self-renewal. Furthermore, we describe a mutation, NANOG L122A, which enhances DNA binding affinity, protein stability, mouse ESC self-renewal, and reprogramming into ground state from primed state pluripotency. Twit Text FOAVip Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25825768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25825768 #FOAvip English Wikipedia <ref>{{Cite pmid|25825768}}</ref> Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells #MMPMID25825768 Hayashi Y; Caboni L; Das D; Yumoto F; Clayton T; Deller MC; Nguyen P; Farr CL; Chiu HJ; Miller MD; Elsliger MA; Deacon AM; Godzik A; Lesley SA; Tomoda K; Conklin BR; Wilson IA; Yamanaka S; Fletterick RJ Proc Natl Acad Sci U S A 2015[Apr]; 112 (15): 4666-71 PMID25825768show ga Maintenance and reprogramming of pluripotency are among the most important issues in stem cell biology and regenerative medicine. Pluripotency is governed by several key transcription factors regulating transcription of other factors. Among these, regulation of OCT4 transcription by NANOG (from Irish myth-ology Tír na nÓg) is a critical interaction. We present here the crystal structure of human NANOG homeodomain in complex with the OCT4 promoter DNA and, through a series of ration-ally designed mutations, we identify key functional residues in the protein?DNA interaction, protein stability, and maintenance of mouse ESC self-renewal. Furthermore, we describe a mutation, NANOG L122A, which enhances DNA binding affinity, protein stability, mouse ESC self-renewal, and reprogramming into ground state from primed state pluripotency. äStructure-based discovery of NANOG variant with enhanced properties to(epmc).pdf DeepDyve Pubget Overpricing