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10.1111/bph.13052 http://scihub22266oqcxt.onion/10.1111/bph.13052 C4403086!4403086!25537552     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2015 ; 172 (9): 2167-78 Nephropedia Template TP {{tp|p=25537552|t=2015. Autophagy: an emerging therapeutic target in vascular diseases |pdf=|usr=}}{{25537552}} gab.com Text Autophagy: an emerging therapeutic target in vascular diseases JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25537552 #FOAvip Autophagy is a cellular catabolic process responsible for the destruction of long-lived proteins and organelles via lysosome-dependent pathway. This process is of great importance in maintaining cellular homeostasis, and deregulated autophagy has been implicated in the pathogenesis of a wide range of diseases. A growing body of evidence suggests that autophagy can be activated in vascular disorders such as atherosclerosis. Autophagy occurs under basal conditions and mediates homeostatic functions in cells but in the setting of pathological states up-regulated autophagy can exert both protective and detrimental functions. Therefore, the precise role of autophagy and its relationship with the progression of the disease need to be clarified. This review highlights recent findings regarding autophagy activity in vascular cells and its potential contribution to vascular disorders with a focus on atherogenesis. Finally, whether the manipulation of autophagy represents a new therapeutic approach to treat or prevent vascular diseases is also discussed. Twit Text FOAVip Autophagy: an emerging therapeutic target in vascular diseases ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=25537552 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25537552 #FOAvip English Wikipedia <ref>{{Cite pmid|25537552}}</ref> Autophagy: an emerging therapeutic target in vascular diseases #MMPMID25537552 Vindis C Br J Pharmacol 2015[May]; 172 (9): 2167-78 PMID25537552show ga Autophagy is a cellular catabolic process responsible for the destruction of long-lived proteins and organelles via lysosome-dependent pathway. This process is of great importance in maintaining cellular homeostasis, and deregulated autophagy has been implicated in the pathogenesis of a wide range of diseases. A growing body of evidence suggests that autophagy can be activated in vascular disorders such as atherosclerosis. Autophagy occurs under basal conditions and mediates homeostatic functions in cells but in the setting of pathological states up-regulated autophagy can exert both protective and detrimental functions. Therefore, the precise role of autophagy and its relationship with the progression of the disease need to be clarified. This review highlights recent findings regarding autophagy activity in vascular cells and its potential contribution to vascular disorders with a focus on atherogenesis. Finally, whether the manipulation of autophagy represents a new therapeutic approach to treat or prevent vascular diseases is also discussed. äAutophagy: an emerging therapeutic target in vascular diseases (epmc).pdf DeepDyve Pubget Overpricing