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10.15252/emmm.201404883 http://scihub22266oqcxt.onion/10.15252/emmm.201404883 C4403049!4403049!25750210     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25750210.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+Mol+Med 2015 ; 7 (4): 488-505 Nephropedia Template TP {{tp|p=25750210|t=2015. A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury |pdf=|usr=}}{{25750210}} gab.com Text A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25750210 #FOAvip Group B streptococci (GBS) are Gram-positive bacteria that cause infections in utero and in newborns. We recently showed that the GBS pigment is hemolytic and increased pigment production promotes bacterial penetration of human placenta. However, mechanisms utilized by the hemolytic pigment to induce host cell lysis and the consequence on fetal injury are not known. Here, we show that the GBS pigment induces membrane permeability in artificial lipid bilayers and host cells. Membrane defects induced by the GBS pigment trigger K+ efflux leading to osmotic lysis of red blood cells or pyroptosis in human macrophages. Macrophages lacking the NLRP3 inflammasome recovered from pigment-induced cell damage. In a murine model of in utero infection, hyperpigmented GBS strains induced fetal injury in both an NLRP3 inflammasome-dependent and NLRP3 inflammasome-independent manner. These results demonstrate that the dual mechanism of action of the bacterial pigment/lipid toxin leading to hemolysis or pyroptosis exacerbates fetal injury and suggest that preventing both activities of the hemolytic lipid is likely critical to reduce GBS fetal injury and preterm birth. Twit Text FOAVip A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=25750210 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25750210 #FOAvip English Wikipedia <ref>{{Cite pmid|25750210}}</ref> A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury #MMPMID25750210 Whidbey C; Vornhagen J; Gendrin C; Boldenow E; Samson JM; Doering K; Ngo L; Ezekwe EAD; Gundlach JH; Elovitz MA; Liggitt D; Duncan JA; Adams Waldorf KM; Rajagopal L EMBO Mol Med 2015[Apr]; 7 (4): 488-505 PMID25750210show ga Group B streptococci (GBS) are Gram-positive bacteria that cause infections in utero and in newborns. We recently showed that the GBS pigment is hemolytic and increased pigment production promotes bacterial penetration of human placenta. However, mechanisms utilized by the hemolytic pigment to induce host cell lysis and the consequence on fetal injury are not known. Here, we show that the GBS pigment induces membrane permeability in artificial lipid bilayers and host cells. Membrane defects induced by the GBS pigment trigger K+ efflux leading to osmotic lysis of red blood cells or pyroptosis in human macrophages. Macrophages lacking the NLRP3 inflammasome recovered from pigment-induced cell damage. In a murine model of in utero infection, hyperpigmented GBS strains induced fetal injury in both an NLRP3 inflammasome-dependent and NLRP3 inflammasome-independent manner. These results demonstrate that the dual mechanism of action of the bacterial pigment/lipid toxin leading to hemolysis or pyroptosis exacerbates fetal injury and suggest that preventing both activities of the hemolytic lipid is likely critical to reduce GBS fetal injury and preterm birth. äA streptococcal lipid toxin induces membrane permeabilization and pyro(epmc).pdf DeepDyve Pubget Overpricing