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10.4049/jimmunol.1402672 http://scihub22266oqcxt.onion/10.4049/jimmunol.1402672 C4402267!4402267!25810392     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (9): 4339-49 Nephropedia Template TP {{tp|p=25810392|t=2015. A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections |pdf=|usr=}}{{25810392}} gab.com Text A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25810392 #FOAvip The ceramide family of lipids plays important roles in both cell structure and signaling in a diverse array of cell types, including immune cells. However, very little is known regarding how ceramide affects the activation of dendritic cells (DCs) in response to viral infection. In this study, we demonstrate that a synthetic ceramide analogue (C8) stimulates DCs to increase the expansion of virus-specific T cells upon virus infection. Exogenously supplied C8 ceramide elevated the expression of DC maturation markers such as MHC class I and co-stimulatory molecules following infection with the Clone 13 strain of lymphocytic choriomeningitis virus (LCMV) or influenza virus. Importantly, ceramide-conditioned, LCMV-infected DCs displayed an increased ability to promote expansion of virus-specific, CD8+ T cells when compared to virus-infected DCs. Furthermore, a locally instilled ceramide analogue significantly increased virus-reactive T cell responses in vivo to both LCMV and influenza virus infections. Collectively, these findings provide new insights into ceramide-mediated regulation of DC responses against virus infection and help us establish a foundation for novel immune-stimulatory therapeutics. Twit Text FOAVip A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25810392 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25810392 #FOAvip English Wikipedia <ref>{{Cite pmid|25810392}}</ref> A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections #MMPMID25810392 Pritzl CJ; Seo YJ; Xia C; Vijayan M; Stokes ZD; Hahm B J Immunol 2015[May]; 194 (9): 4339-49 PMID25810392show ga The ceramide family of lipids plays important roles in both cell structure and signaling in a diverse array of cell types, including immune cells. However, very little is known regarding how ceramide affects the activation of dendritic cells (DCs) in response to viral infection. In this study, we demonstrate that a synthetic ceramide analogue (C8) stimulates DCs to increase the expansion of virus-specific T cells upon virus infection. Exogenously supplied C8 ceramide elevated the expression of DC maturation markers such as MHC class I and co-stimulatory molecules following infection with the Clone 13 strain of lymphocytic choriomeningitis virus (LCMV) or influenza virus. Importantly, ceramide-conditioned, LCMV-infected DCs displayed an increased ability to promote expansion of virus-specific, CD8+ T cells when compared to virus-infected DCs. Furthermore, a locally instilled ceramide analogue significantly increased virus-reactive T cell responses in vivo to both LCMV and influenza virus infections. Collectively, these findings provide new insights into ceramide-mediated regulation of DC responses against virus infection and help us establish a foundation for novel immune-stimulatory therapeutics. äA ceramide analogue stimulates dendritic cells to promote T cell respo(epmc).pdf DeepDyve Pubget Overpricing