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10.4049/jimmunol.1401940 http://scihub22266oqcxt.onion/10.4049/jimmunol.1401940 C4402265!4402265!25821219     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 194 (9): 4387-96 Nephropedia Template TP {{tp|p=25821219|t=2015. Antibodies generated against streptococci protect in a mouse model of disseminated aspergillosis1 |pdf=|usr=}}{{25821219}} gab.com Text Antibodies generated against streptococci protect in a mouse model of disseminated aspergillosis1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25821219 #FOAvip Invasive Aspergillosis (I.A.) resulting from infection by Aspergillus fumagatus (A.f.) is a leading cause of death in immunosuppressed populations. There are limited therapeutic options for this disease and currently no vaccine. There is evidence some anti-A.f. monoclonal antibodies can provide protection against I.A. However, vaccine development has been impeded by a paucity of immunological targets on this organism demonstrated to provide protective responses. Sialylated oligosaccharide epitopes found on a variety of pathogens including fungi and Group B Streptococci (GBS) are thought to be major virulence factors of these organisms facilitating pathogen attachment to host cells and modulating complement activation and phagocytosis. As some of these oligosaccharide structures are conserved across kingdoms, we screened a panel monoclonal antibodies raised against GBS serotypes for reactivity to A.f. This approach revealed that SMB19, a GBSIb type-specific mAb, reacts with A.f. conidia and hyphae. The presence of this antibody in mice, as a result of passive or active immunization, or by enforced expression of the SMB19 heavy chain as a transgene, results in significant protection in both intravenous and airway-induced models of I.A. This study demonstrates that some antibodies generated against bacterial polysaccharides engage fungal pathogens and promote their clearance in vivo and thus provide rationale of alternative strategies for the development of vaccines or therapeutic monoclonal antibodies against these organisms. Twit Text FOAVip Antibodies generated against streptococci protect in a mouse model of disseminated aspergillosis1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25821219 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25821219 #FOAvip English Wikipedia <ref>{{Cite pmid|25821219}}</ref> Antibodies generated against streptococci protect in a mouse model of disseminated aspergillosis1 #MMPMID25821219 Wharton RE; Stefanov EK; King RG; Kearney JF J Immunol 2015[May]; 194 (9): 4387-96 PMID25821219show ga Invasive Aspergillosis (I.A.) resulting from infection by Aspergillus fumagatus (A.f.) is a leading cause of death in immunosuppressed populations. There are limited therapeutic options for this disease and currently no vaccine. There is evidence some anti-A.f. monoclonal antibodies can provide protection against I.A. However, vaccine development has been impeded by a paucity of immunological targets on this organism demonstrated to provide protective responses. Sialylated oligosaccharide epitopes found on a variety of pathogens including fungi and Group B Streptococci (GBS) are thought to be major virulence factors of these organisms facilitating pathogen attachment to host cells and modulating complement activation and phagocytosis. As some of these oligosaccharide structures are conserved across kingdoms, we screened a panel monoclonal antibodies raised against GBS serotypes for reactivity to A.f. This approach revealed that SMB19, a GBSIb type-specific mAb, reacts with A.f. conidia and hyphae. The presence of this antibody in mice, as a result of passive or active immunization, or by enforced expression of the SMB19 heavy chain as a transgene, results in significant protection in both intravenous and airway-induced models of I.A. This study demonstrates that some antibodies generated against bacterial polysaccharides engage fungal pathogens and promote their clearance in vivo and thus provide rationale of alternative strategies for the development of vaccines or therapeutic monoclonal antibodies against these organisms. äAntibodies generated against streptococci protect in a mouse model of (epmc).pdf DeepDyve Pubget Overpricing