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10.1016/j.schres.2014.09.041 http://scihub22266oqcxt.onion/10.1016/j.schres.2014.09.041 C4402105!4402105!25449711     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Schizophr+Res 2015 ; 167 (ä): 4-11 Nephropedia Template TP {{tp|p=25449711|t=2015. GABAergic mechanisms of hippocampal hyperactivity in schizophrenia |pdf=|usr=}}{{25449711}} gab.com Text GABAergic mechanisms of hippocampal hyperactivity in schizophrenia JO: Schizophr Res http://www.kidney.de/pget.php?&tw=1&pmid=25449711 #FOAvip Schizophrenia is associated with abnormalities of hippocampal structure and function. Neuroimaging studies have shown that the hippocampus is hyperactive in schizophrenia. Here we explore GABAergic mechanisms of this hippocampal hyperactivity.The initial evidence for GABAergic abnormalities of the hippocampus in schizophrenia came from post-mortem studies of interneuron number, protein expression, and gene expression. These studies revealed marked decreases in gene and protein expression of somatostatin-positive and parvalbumin-positive interneurons, and indicated reduced interneuron numbers. Animal studies of decreased parvalbumin and NMDA-receptor function have shown that selective abnormalities of hippocampal interneurons mimic some of the cognitive deficits and clinical features of schizophrenia.The post-mortem and animal studies are consistent with the neuroimaging finding of increased hippocampal activity in schizophrenia, which can explain some of the psychotic symptoms and cognitive deficits. Taken together, these findings may guide the development of biomarkers and the development of new treatments for psychosis. Twit Text FOAVip GABAergic mechanisms of hippocampal hyperactivity in schizophrenia ????Schizophr Res http://www.kidney.de/pget.php?&tw=1&pmid=25449711 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25449711 #FOAvip English Wikipedia <ref>{{Cite pmid|25449711}}</ref> GABAergic mechanisms of hippocampal hyperactivity in schizophrenia #MMPMID25449711 Heckers S; Konradi C Schizophr Res 2015[Sep]; 167 (ä): 4-11 PMID25449711show ga Schizophrenia is associated with abnormalities of hippocampal structure and function. Neuroimaging studies have shown that the hippocampus is hyperactive in schizophrenia. Here we explore GABAergic mechanisms of this hippocampal hyperactivity.The initial evidence for GABAergic abnormalities of the hippocampus in schizophrenia came from post-mortem studies of interneuron number, protein expression, and gene expression. These studies revealed marked decreases in gene and protein expression of somatostatin-positive and parvalbumin-positive interneurons, and indicated reduced interneuron numbers. Animal studies of decreased parvalbumin and NMDA-receptor function have shown that selective abnormalities of hippocampal interneurons mimic some of the cognitive deficits and clinical features of schizophrenia.The post-mortem and animal studies are consistent with the neuroimaging finding of increased hippocampal activity in schizophrenia, which can explain some of the psychotic symptoms and cognitive deficits. Taken together, these findings may guide the development of biomarkers and the development of new treatments for psychosis. äGABAergic mechanisms of hippocampal hyperactivity in schizophrenia (epmc).pdf DeepDyve Pubget Overpricing