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10.1016/j.cell.2005.06.015 http://scihub22266oqcxt.onion/10.1016/j.cell.2005.06.015 C4401993!4401993!16096058     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2005 ; 122 (3): 379-91 Nephropedia Template TP {{tp|p=16096058|t=2005. Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets |pdf=|usr=}}{{16096058}} gab.com Text Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=16096058 #FOAvip Platelets are specialized hemostatic cells that circulate in the blood as anucleate cytoplasts. We report that platelets unexpectedly possess a functional spliceosome, a complex that processes pre-mRNAs in the nuclei of other cell types. Spliceosome components are present in the cytoplasm of human megakaryocytes and in proplatelets that extend from megakaryocytes. Primary human platelets also contain essential spliceosome factors including small nuclear RNAs, splicing proteins, and endogenous pre-mRNAs. In response to integrin engagement and surface receptor activation, platelets precisely excise introns from interleukin-1? pre-mRNA, yielding a mature message that is translated into protein. Signal-dependent splicing is a novel function of platelets that demonstrates remarkable specialization in the regulatory repertoire of this anucleate cell. While this mechanism may be unique to platelets, it also suggests previously unrecognized diversity regarding the functional roles of the spliceosome in eukaryotic cells. Twit Text FOAVip Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=16096058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=16096058 #FOAvip English Wikipedia <ref>{{Cite pmid|16096058}}</ref> Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets #MMPMID16096058 Denis MM; Tolley ND; Bunting M; Schwertz H; Jiang H; Lindemann S; Yost CC; Rubner FJ; Albertine KH; Swoboda KJ; Fratto CM; Tolley E; Kraiss LW; McIntyre TM; Zimmerman GA; Weyrich AS Cell 2005[Aug]; 122 (3): 379-91 PMID16096058show ga Platelets are specialized hemostatic cells that circulate in the blood as anucleate cytoplasts. We report that platelets unexpectedly possess a functional spliceosome, a complex that processes pre-mRNAs in the nuclei of other cell types. Spliceosome components are present in the cytoplasm of human megakaryocytes and in proplatelets that extend from megakaryocytes. Primary human platelets also contain essential spliceosome factors including small nuclear RNAs, splicing proteins, and endogenous pre-mRNAs. In response to integrin engagement and surface receptor activation, platelets precisely excise introns from interleukin-1? pre-mRNA, yielding a mature message that is translated into protein. Signal-dependent splicing is a novel function of platelets that demonstrates remarkable specialization in the regulatory repertoire of this anucleate cell. While this mechanism may be unique to platelets, it also suggests previously unrecognized diversity regarding the functional roles of the spliceosome in eukaryotic cells. äEscaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in A(epmc).pdf DeepDyve Pubget Overpricing