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10.1371/journal.ppat.1004839 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1004839 C4401782!4401782!25884716     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2015 ; 11 (4): ä Nephropedia Template TP {{tp|p=25884716|t=2015. A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development |pdf=|usr=}}{{25884716}} gab.com Text A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=25884716 #FOAvip Survival of M. tuberculosis in host macrophages requires the eukaryotic-type protein kinase G, PknG, but the underlying mechanism has remained unknown. Here, we show that PknG is an integral component of a novel redox homeostaticsystem, RHOCS, which includes the ribosomal protein L13 and RenU, a Nudix hydrolase encoded by a gene adjacent to pknG. Studies in M. smegmatis showed that PknG expression is uniquely induced by NADH, which plays a key role in metabolism and redox homeostasis. In vitro, RenU hydrolyses FAD, ADP-ribose and NADH, but not NAD+. Absence of RHOCS activities in vivo causes NADH and FAD accumulation, and increased susceptibility to oxidative stress. We show that PknG phosphorylates L13 and promotes its cytoplasmic association with RenU, and the phosphorylated L13 accelerates the RenU-catalyzed NADH hydrolysis. Importantly, interruption of RHOCS leads to impaired mycobacterial biofilms and reduced survival of M. tuberculosis in macrophages. Thus, RHOCS represents a checkpoint in the developmental program required for mycobacterial growth in these environments. Twit Text FOAVip A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=25884716 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25884716 #FOAvip English Wikipedia <ref>{{Cite pmid|25884716}}</ref> A Redox Regulatory System Critical for Mycobacterial Survival in Macrophages and Biofilm Development #MMPMID25884716 Wolff KA; de la Peña AH; Nguyen HT; Pham TH; Amzel LM; Gabelli SB; Nguyen L PLoS Pathog 2015[Apr]; 11 (4): ä PMID25884716show ga Survival of M. tuberculosis in host macrophages requires the eukaryotic-type protein kinase G, PknG, but the underlying mechanism has remained unknown. Here, we show that PknG is an integral component of a novel redox homeostaticsystem, RHOCS, which includes the ribosomal protein L13 and RenU, a Nudix hydrolase encoded by a gene adjacent to pknG. Studies in M. smegmatis showed that PknG expression is uniquely induced by NADH, which plays a key role in metabolism and redox homeostasis. In vitro, RenU hydrolyses FAD, ADP-ribose and NADH, but not NAD+. Absence of RHOCS activities in vivo causes NADH and FAD accumulation, and increased susceptibility to oxidative stress. We show that PknG phosphorylates L13 and promotes its cytoplasmic association with RenU, and the phosphorylated L13 accelerates the RenU-catalyzed NADH hydrolysis. Importantly, interruption of RHOCS leads to impaired mycobacterial biofilms and reduced survival of M. tuberculosis in macrophages. Thus, RHOCS represents a checkpoint in the developmental program required for mycobacterial growth in these environments. äA Redox Regulatory System Critical for Mycobacterial Survival in Macro(epmc).pdf DeepDyve Pubget Overpricing