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10.1371/journal.pone.0125906 http://scihub22266oqcxt.onion/10.1371/journal.pone.0125906 C4401748!4401748 !25885273     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25885273 &cmd=llinks): Failed to open stream: HTTP request failed! 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Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity |pdf=|usr=}}{{25885273 }} gab.com Text Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25885273 #FOAvip The NADPH oxidase of neutrophils, essential for innate immunity, passes electrons across the phagocytic membrane to form superoxide in the phagocytic vacuole. Activity of the oxidase requires that charge movements across the vacuolar membrane are balanced. Using the pH indicator SNARF, we measured changes in pH in the phagocytic vacuole and cytosol of neutrophils. In human cells, the vacuolar pH rose to ~9, and the cytosol acidified slightly. By contrast, in Hvcn1 knock out mouse neutrophils, the vacuolar pH rose above 11, vacuoles swelled, and the cytosol acidified excessively, demonstrating that ordinarily this channel plays an important role in charge compensation. Proton extrusion was not diminished in Hvcn1-/- mouse neutrophils arguing against its role in maintaining pH homeostasis across the plasma membrane. Conditions in the vacuole are optimal for bacterial killing by the neutral proteases, cathepsin G and elastase, and not by myeloperoxidase, activity of which was unphysiologically low at alkaline pH. Twit Text FOAVip Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=25885273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25885273 #FOAvip English Wikipedia <ref>{{Cite pmid|25885273 }}</ref> Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and has consequences for myeloperoxidase activity #MMPMID25885273 Levine AP ; Duchen MR ; de Villiers S ; Rich PR ; Segal AW PLoS One 2015[]; 10 (4 ): e0125906 PMID25885273 show ga The NADPH oxidase of neutrophils, essential for innate immunity, passes electrons across the phagocytic membrane to form superoxide in the phagocytic vacuole. Activity of the oxidase requires that charge movements across the vacuolar membrane are balanced. Using the pH indicator SNARF, we measured changes in pH in the phagocytic vacuole and cytosol of neutrophils. In human cells, the vacuolar pH rose to ~9, and the cytosol acidified slightly. By contrast, in Hvcn1 knock out mouse neutrophils, the vacuolar pH rose above 11, vacuoles swelled, and the cytosol acidified excessively, demonstrating that ordinarily this channel plays an important role in charge compensation. Proton extrusion was not diminished in Hvcn1-/- mouse neutrophils arguing against its role in maintaining pH homeostasis across the plasma membrane. Conditions in the vacuole are optimal for bacterial killing by the neutral proteases, cathepsin G and elastase, and not by myeloperoxidase, activity of which was unphysiologically low at alkaline pH. |*Phagocytosis [MESH] |Animals [MESH] |Cathepsin G/metabolism [MESH] |Cells, Cultured [MESH] |Cytoplasm/chemistry/metabolism [MESH] |Humans [MESH] |Hydrogen-Ion Concentration [MESH] |Ion Channels/genetics/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Neutrophils/*metabolism/physiology [MESH] |Pancreatic Elastase/metabolism [MESH] |Peroxidase/*metabolism [MESH] |Respiratory Burst [MESH]Alkalinity of neutrophil phagocytic vacuoles is modulated by HVCN1 and(epmc).pdf DeepDyve Pubget Overpricing