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10.1371/journal.pbio.1002125 http://scihub22266oqcxt.onion/10.1371/journal.pbio.1002125 C4401640!4401640!25884288     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Biol 2015 ; 13 (4): ä Nephropedia Template TP {{tp|p=25884288|t=2015. Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression |pdf=|usr=}}{{25884288}} gab.com Text Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression JO: PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=25884288 #FOAvip Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migration of endothelial cells, representing anastomosis in reverse. Establishing and analyzing the first axial polarity map of all endothelial cells in a remodeling vascular network, we propose that balanced movement of cells maintains the primitive plexus under low shear conditions in a metastable dynamic state. We predict that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/shear segments and regression of adjacent low flow/shear segments. Twit Text FOAVip Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression ????PLoS Biol http://www.kidney.de/pget.php?&tw=1&pmid=25884288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25884288 #FOAvip English Wikipedia <ref>{{Cite pmid|25884288}}</ref> Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression #MMPMID25884288 Franco CA; Jones ML; Bernabeu MO; Geudens I; Mathivet T; Rosa A; Lopes FM; Lima AP; Ragab A; Collins RT; Phng LK; Coveney PV; Gerhardt H PLoS Biol 2015[Apr]; 13 (4): ä PMID25884288show ga Patterning of functional blood vessel networks is achieved by pruning of superfluous connections. The cellular and molecular principles of vessel regression are poorly understood. Here we show that regression is mediated by dynamic and polarized migration of endothelial cells, representing anastomosis in reverse. Establishing and analyzing the first axial polarity map of all endothelial cells in a remodeling vascular network, we propose that balanced movement of cells maintains the primitive plexus under low shear conditions in a metastable dynamic state. We predict that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/shear segments and regression of adjacent low flow/shear segments. äDynamic Endothelial Cell Rearrangements Drive Developmental Vessel Reg(epmc).pdf DeepDyve Pubget Overpricing