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10.1371/journal.ppat.1004827 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1004827 C4401519!4401519!25884622     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2015 ; 11 (4): ä Nephropedia Template TP {{tp|p=25884622|t=2015. Neutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to Staphylococcus aureus |pdf=|usr=}}{{25884622}} gab.com Text Neutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to Staphylococcus aureus JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=25884622 #FOAvip Neutrophils form the first line of host defense against bacterial pathogens. They are rapidly mobilized to sites of infection where they help marshal host defenses and remove bacteria by phagocytosis. While splenic neutrophils promote marginal zone B cell antibody production in response to administered T cell independent antigens, whether neutrophils shape humoral immunity in other lymphoid organs is controversial. Here we investigate the neutrophil influx following the local injection of Staphylococcus aureus adjacent to the inguinal lymph node and determine neutrophil impact on the lymph node humoral response. Using intravital microscopy we show that local immunization or infection recruits neutrophils from the blood to lymph nodes in waves. The second wave occurs temporally with neutrophils mobilized from the bone marrow. Within lymph nodes neutrophils infiltrate the medulla and interfollicular areas, but avoid crossing follicle borders. In vivo neutrophils form transient and long-lived interactions with B cells and plasma cells, and their depletion augments production of antigen-specific IgG and IgM in the lymph node. In vitro activated neutrophils establish synapse- and nanotube-like interactions with B cells and reduce B cell IgM production in a TGF- ?1 dependent manner. Our data reveal that neutrophils mobilized from the bone marrow in response to a local bacterial challenge dampen the early humoral response in the lymph node. Twit Text FOAVip Neutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to Staphylococcus aureus ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=25884622 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25884622 #FOAvip English Wikipedia <ref>{{Cite pmid|25884622}}</ref> Neutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to Staphylococcus aureus #MMPMID25884622 Kamenyeva O; Boularan C; Kabat J; Cheung GYC; Cicala C; Yeh AJ; Chan JL; Periasamy S; Otto M; Kehrl JH PLoS Pathog 2015[Apr]; 11 (4): ä PMID25884622show ga Neutrophils form the first line of host defense against bacterial pathogens. They are rapidly mobilized to sites of infection where they help marshal host defenses and remove bacteria by phagocytosis. While splenic neutrophils promote marginal zone B cell antibody production in response to administered T cell independent antigens, whether neutrophils shape humoral immunity in other lymphoid organs is controversial. Here we investigate the neutrophil influx following the local injection of Staphylococcus aureus adjacent to the inguinal lymph node and determine neutrophil impact on the lymph node humoral response. Using intravital microscopy we show that local immunization or infection recruits neutrophils from the blood to lymph nodes in waves. The second wave occurs temporally with neutrophils mobilized from the bone marrow. Within lymph nodes neutrophils infiltrate the medulla and interfollicular areas, but avoid crossing follicle borders. In vivo neutrophils form transient and long-lived interactions with B cells and plasma cells, and their depletion augments production of antigen-specific IgG and IgM in the lymph node. In vitro activated neutrophils establish synapse- and nanotube-like interactions with B cells and reduce B cell IgM production in a TGF- ?1 dependent manner. Our data reveal that neutrophils mobilized from the bone marrow in response to a local bacterial challenge dampen the early humoral response in the lymph node. äNeutrophil Recruitment to Lymph Nodes Limits Local Humoral Response to(epmc).pdf DeepDyve Pubget Overpricing