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10.1159/000373984 http://scihub22266oqcxt.onion/10.1159/000373984 C4401473!4401473!25832005     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Physiol+Biochem 2015 ; 35 (5): 1719-28 Nephropedia Template TP {{tp|p=25832005|t=2015. Stem Cell Conditioned Culture Media Attenuated Albumin-Induced Epithelial? Mesenchymal Transition in Renal Tubular Cells |pdf=|usr=}}{{25832005}} gab.com Text Stem Cell Conditioned Culture Media Attenuated Albumin-Induced Epithelial Mesenchymal Transition in Renal Tubular Cells JO: Cell Physiol Biochem http://www.kidney.de/pget.php?&tw=1&pmid=25832005 #FOAvip Background: Proteinuria-induced epithelial-mesenchymal transition (EMT) plays an important role in progressive renal tubulointerstitial fibrosis in chronic renal disease. Stem cell therapy has been used for different diseases. Stem cell conditioned culture media (SCM) exhibits similar beneficial effects as stem cell therapy. The present study tested the hypothesis that SCM inhibits albumin-induced EMT in cultured renal tubular cells. Methods: Rat renal tubular cells were treated with/without albumin (20 ?mg/ml) plus SCM or control cell media (CCM). EMT markers and inflammatory factors were measured by Western blot and fluorescent images. Results: Albumin induced EMT as shown by significant decreases in levels of epithelial marker E-cadherin, increases in mesenchymal markers fibroblast-specific protein 1 and ?-smooth muscle actin, and elevations in collagen I. SCM inhibited all these changes. Meanwhile, albumin induced NF-?B translocation from cytosol into nucleus and that SCM blocked the nuclear translocation of NF-?B. Albumin also increased the levels of pro-inflammatory factor monocyte chemoattractant protein-1 (MCP)-1 by nearly 30 fold compared with control. SCM almost abolished albumin-induced increase of MCP-1. Conclusion: These results suggest that SCM attenuated albumin-induced EMT in renal tubular cells via inhibiting activation of inflammatory factors, which may serve as a new therapeutic approach for chronic kidney diseases. Twit Text FOAVip Stem Cell Conditioned Culture Media Attenuated Albumin-Induced Epithelial Mesenchymal Transition in Renal Tubular Cells ????Cell Physiol Biochem http://www.kidney.de/pget.php?&tw=1&pmid=25832005 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25832005 #FOAvip English Wikipedia <ref>{{Cite pmid|25832005}}</ref> Stem Cell Conditioned Culture Media Attenuated Albumin-Induced Epithelial? Mesenchymal Transition in Renal Tubular Cells #MMPMID25832005 Hu J; Zhu Q; Li PL; Wang W; Yi F; Li N Cell Physiol Biochem 2015[]; 35 (5): 1719-28 PMID25832005show ga Background: Proteinuria-induced epithelial-mesenchymal transition (EMT) plays an important role in progressive renal tubulointerstitial fibrosis in chronic renal disease. Stem cell therapy has been used for different diseases. Stem cell conditioned culture media (SCM) exhibits similar beneficial effects as stem cell therapy. The present study tested the hypothesis that SCM inhibits albumin-induced EMT in cultured renal tubular cells. Methods: Rat renal tubular cells were treated with/without albumin (20 ?mg/ml) plus SCM or control cell media (CCM). EMT markers and inflammatory factors were measured by Western blot and fluorescent images. Results: Albumin induced EMT as shown by significant decreases in levels of epithelial marker E-cadherin, increases in mesenchymal markers fibroblast-specific protein 1 and ?-smooth muscle actin, and elevations in collagen I. SCM inhibited all these changes. Meanwhile, albumin induced NF-?B translocation from cytosol into nucleus and that SCM blocked the nuclear translocation of NF-?B. Albumin also increased the levels of pro-inflammatory factor monocyte chemoattractant protein-1 (MCP)-1 by nearly 30 fold compared with control. SCM almost abolished albumin-induced increase of MCP-1. Conclusion: These results suggest that SCM attenuated albumin-induced EMT in renal tubular cells via inhibiting activation of inflammatory factors, which may serve as a new therapeutic approach for chronic kidney diseases. äStem Cell Conditioned Culture Media Attenuated Albumin-Induced Epithel(epmc).pdf DeepDyve Pubget Overpricing