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2015 ; 2015
(ä): bav030
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Causal biological network database: a comprehensive platform of causal biological
network models focused on the pulmonary and vascular systems
#MMPMID25887162
Boué S
; Talikka M
; Westra JW
; Hayes W
; Di Fabio A
; Park J
; Schlage WK
; Sewer A
; Fields B
; Ansari S
; Martin F
; Veljkovic E
; Kenney R
; Peitsch MC
; Hoeng J
Database (Oxford)
2015[]; 2015
(ä): bav030
PMID25887162
show ga
With the wealth of publications and data available, powerful and transparent
computational approaches are required to represent measured data and scientific
knowledge in a computable and searchable format. We developed a set of biological
network models, scripted in the Biological Expression Language, that reflect
causal signaling pathways across a wide range of biological processes, including
cell fate, cell stress, cell proliferation, inflammation, tissue repair and
angiogenesis in the pulmonary and cardiovascular context. This comprehensive
collection of networks is now freely available to the scientific community in a
centralized web-based repository, the Causal Biological Network database, which
is composed of over 120 manually curated and well annotated biological network
models and can be accessed at http://causalbionet.com. The website accesses a
MongoDB, which stores all versions of the networks as JSON objects and allows
users to search for genes, proteins, biological processes, small molecules and
keywords in the network descriptions to retrieve biological networks of interest.
The content of the networks can be visualized and browsed. Nodes and edges can be
filtered and all supporting evidence for the edges can be browsed and is linked
to the original articles in PubMed. Moreover, networks may be downloaded for
further visualization and evaluation. Database URL: http://causalbionet.com