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10.1016/S1473-3099(14)70772-8 http://scihub22266oqcxt.onion/10.1016/S1473-3099(14)70772-8 C4401121!4401121!25278220     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25278220&cmd=llinks): Failed to open stream: HTTP request failed! 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A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium |pdf=|usr=}}{{25278220}} gab.com Text A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium JO: Lancet Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=25278220 #FOAvip Cryptosporidium spp are well recognised as causes of diarrhoeal disease during waterborne epidemics and in immunocompromised hosts. Studies have also drawn attention to an underestimated global burden and suggest major gaps in optimum diagnosis, treatment, and immunisation. Cryptosporidiosis is increasingly identified as an important cause of morbidity and mortality worldwide. Studies in low-resource settings and high-income countries have confirmed the importance of cryptosporidium as a cause of diarrhoea and childhood malnutrition. Diagnostic tests for cryptosporidium infection are suboptimum, necessitating specialised tests that are often insensitive. Antigen-detection and PCR improve sensitivity, and multiplexed antigen detection and molecular assays are underused. Therapy has some effect in healthy hosts and no proven efficacy in patients with AIDS. Use of cryptosporidium genomes has helped to identify promising therapeutic targets, and drugs are in development, but methods to assess the efficacy in vitro and in animals are not well standardised. Partial immunity after exposure suggests the potential for successful vaccines, and several are in development; however, surrogates of protection are not well defined. Improved methods for propagation and genetic manipulation of the organism would be significant advances. Twit Text FOAVip A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium ????Lancet Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=25278220 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25278220 #FOAvip English Wikipedia <ref>{{Cite pmid|25278220}}</ref> A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium #MMPMID25278220 Checkley W; White AC; Jaganath D; Arrowood MJ; Chalmers RM; Chen XM; Fayer R; Griffiths JK; Guerrant RL; Hedstrom L; Huston CD; Kotloff KL; Kang G; Mead JR; Miller M; Petri WA; Priest JW; Roos DS; Striepen B; Thompson RCA; Ward HD; Van Voorhis WA; Xiao L; Zhu G; Houpt ER Lancet Infect Dis 2015[Jan]; 15 (1): 85-94 PMID25278220show ga Cryptosporidium spp are well recognised as causes of diarrhoeal disease during waterborne epidemics and in immunocompromised hosts. Studies have also drawn attention to an underestimated global burden and suggest major gaps in optimum diagnosis, treatment, and immunisation. Cryptosporidiosis is increasingly identified as an important cause of morbidity and mortality worldwide. Studies in low-resource settings and high-income countries have confirmed the importance of cryptosporidium as a cause of diarrhoea and childhood malnutrition. Diagnostic tests for cryptosporidium infection are suboptimum, necessitating specialised tests that are often insensitive. Antigen-detection and PCR improve sensitivity, and multiplexed antigen detection and molecular assays are underused. Therapy has some effect in healthy hosts and no proven efficacy in patients with AIDS. Use of cryptosporidium genomes has helped to identify promising therapeutic targets, and drugs are in development, but methods to assess the efficacy in vitro and in animals are not well standardised. Partial immunity after exposure suggests the potential for successful vaccines, and several are in development; however, surrogates of protection are not well defined. Improved methods for propagation and genetic manipulation of the organism would be significant advances. äA review of the global burden, novel diagnostics, therapeutics, and va(epmc).pdf DeepDyve Pubget Overpricing