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10.1038/nm.2961 http://scihub22266oqcxt.onion/10.1038/nm.2961 C4401084!4401084 !23086477     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23086477 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Med 2012 ; 18 (11 ): 1643-50 Nephropedia Template TP {{tp|p=23086477 |t=2012. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun |pdf=|usr=}}{{23086477 }} gab.com Text The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=23086477 #FOAvip Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the development of various diseases, including heart failure. However, the molecular mechanisms that regulate activation of this signaling pathway are not completely understood. Here we show that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling. SIRT6-deficient mice developed cardiac hypertrophy and heart failure, whereas SIRT6 transgenic mice were protected from hypertrophic stimuli, indicating that SIRT6 acts as a negative regulator of cardiac hypertrophy. SIRT6-deficient mouse hearts showed hyperactivation of IGF signaling-related genes and their downstream targets. Mechanistically, SIRT6 binds to and suppresses the promoter of IGF signaling-related genes by interacting with c-Jun and deacetylating histone 3 at Lys9 (H3K9). We also found reduced SIRT6 expression in human failing hearts. These findings disclose a new link between SIRT6 and IGF-Akt signaling and implicate SIRT6 in the development of cardiac hypertrophy and failure. Twit Text FOAVip The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=23086477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23086477 #FOAvip English Wikipedia <ref>{{Cite pmid|23086477 }}</ref> The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun #MMPMID23086477 Sundaresan NR ; Vasudevan P ; Zhong L ; Kim G ; Samant S ; Parekh V ; Pillai VB ; Ravindra PV ; Gupta M ; Jeevanandam V ; Cunningham JM ; Deng CX ; Lombard DB ; Mostoslavsky R ; Gupta MP Nat Med 2012[Nov]; 18 (11 ): 1643-50 PMID23086477 show ga Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the development of various diseases, including heart failure. However, the molecular mechanisms that regulate activation of this signaling pathway are not completely understood. Here we show that sirtuin 6 (SIRT6), a nuclear histone deacetylase, functions at the level of chromatin to directly attenuate IGF-Akt signaling. SIRT6-deficient mice developed cardiac hypertrophy and heart failure, whereas SIRT6 transgenic mice were protected from hypertrophic stimuli, indicating that SIRT6 acts as a negative regulator of cardiac hypertrophy. SIRT6-deficient mouse hearts showed hyperactivation of IGF signaling-related genes and their downstream targets. Mechanistically, SIRT6 binds to and suppresses the promoter of IGF signaling-related genes by interacting with c-Jun and deacetylating histone 3 at Lys9 (H3K9). We also found reduced SIRT6 expression in human failing hearts. These findings disclose a new link between SIRT6 and IGF-Akt signaling and implicate SIRT6 in the development of cardiac hypertrophy and failure. |*Cardiomegaly/genetics/metabolism [MESH] |*Heart Failure/genetics/metabolism [MESH] |*JNK Mitogen-Activated Protein Kinases [MESH] |*Oncogene Protein v-akt/genetics/metabolism [MESH] |*Sirtuins/deficiency/genetics/metabolism [MESH] |Acetylation [MESH] |Animals [MESH] |Chromatin/genetics/metabolism [MESH] |DNA-Binding Proteins/genetics/metabolism [MESH] |Histone Demethylases/metabolism [MESH] |Insulin-Like Growth Factor I/genetics/metabolism [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Promoter Regions, Genetic [MESH]The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac (epmc).pdf DeepDyve Pubget Overpricing