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10.1042/CS20130152 http://scihub22266oqcxt.onion/10.1042/CS20130152 C4401013!4401013!23905758     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Sci+(Lond) 2014 ; 126 (3): 223-32 Nephropedia Template TP {{tp|p=23905758|t=2014. CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in COPD CD8 cells |pdf=|usr=}}{{23905758}} gab.com Text CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in COPD CD8 cells JO: Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=23905758 #FOAvip Background: There are increased numbers of pulmonary CD8 lymphocytes in COPD. Calcium-release activation calcium (CRAC) channels play a central role in lymphocyte activation though the regulation of the transcription factor nuclear factor of activated T cells (NFAT). Objective: We studied the expression of NFAT in COPD lungs compared to controls, and evaluated the effects of CRAC inhibition compared to corticosteroids on NFAT activation and cytokine production from COPD CD8 cells. Methods: The effects of the corticosteroid dexamethasone, the calcineurin inhibitor cyclosporin and the CRAC inhibitor synta-66 were studied on cytokine production and NFAT activation using peripheral blood and isolated pulmonary CD8 cells. NFAT1 and CD8 co-expression in the lungs was compared in COPD and controls using combined immunohistochemistry and immunofluorescence. Results: NFAT inhibition with either cyclosporin or synta-66 resulted in significantly greater maximal inhibition of cytokines than dexamethasone in both peripheral blood and pulmonary CD8 cells (e.g. > 95% inhibition of IFN? production from pulmonary CD8 cells using cyclosporin and synta-66 compared to <50% using dexamethasone). The absolute number of pulmonary CD8 cells co-expressing NFAT1 was significantly raised in COPD lung compared to controls, but the percentage of CD8 cells co-expressing NFAT1 was similar between COPD and controls (80.7 % vs 78.5 % respectively, p=0.3). Conclusions: Inhibition of NFAT using the CRAC inhibitor synta-66 produces greater anti-inflammatory effects on COPD CD8 cells than corticosteroids. NFAT is expressed in a high proportion of COPD pulmonary CD8 cells. Twit Text FOAVip CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in COPD CD8 cells ????Clin Sci (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=23905758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23905758 #FOAvip English Wikipedia <ref>{{Cite pmid|23905758}}</ref> CRAC channel inhibition produces greater anti-inflammatory effects than glucocorticoids in COPD CD8 cells #MMPMID23905758 Grundy S; Kaur M; Plumb J; Reynolds S; Hall S; House D; Begg M; Ray D; Singh D Clin Sci (Lond) 2014[Feb]; 126 (3): 223-32 PMID23905758show ga Background: There are increased numbers of pulmonary CD8 lymphocytes in COPD. Calcium-release activation calcium (CRAC) channels play a central role in lymphocyte activation though the regulation of the transcription factor nuclear factor of activated T cells (NFAT). Objective: We studied the expression of NFAT in COPD lungs compared to controls, and evaluated the effects of CRAC inhibition compared to corticosteroids on NFAT activation and cytokine production from COPD CD8 cells. Methods: The effects of the corticosteroid dexamethasone, the calcineurin inhibitor cyclosporin and the CRAC inhibitor synta-66 were studied on cytokine production and NFAT activation using peripheral blood and isolated pulmonary CD8 cells. NFAT1 and CD8 co-expression in the lungs was compared in COPD and controls using combined immunohistochemistry and immunofluorescence. Results: NFAT inhibition with either cyclosporin or synta-66 resulted in significantly greater maximal inhibition of cytokines than dexamethasone in both peripheral blood and pulmonary CD8 cells (e.g. > 95% inhibition of IFN? production from pulmonary CD8 cells using cyclosporin and synta-66 compared to <50% using dexamethasone). The absolute number of pulmonary CD8 cells co-expressing NFAT1 was significantly raised in COPD lung compared to controls, but the percentage of CD8 cells co-expressing NFAT1 was similar between COPD and controls (80.7 % vs 78.5 % respectively, p=0.3). Conclusions: Inhibition of NFAT using the CRAC inhibitor synta-66 produces greater anti-inflammatory effects on COPD CD8 cells than corticosteroids. NFAT is expressed in a high proportion of COPD pulmonary CD8 cells. äCRAC channel inhibition produces greater anti-inflammatory effects tha(epmc).pdf DeepDyve Pubget Overpricing