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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.stemcr.2015.02.002 http://scihub22266oqcxt.onion/10.1016/j.stemcr.2015.02.002 C4400646!4400646 !25754206     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25754206 &cmd=llinks): Failed to open stream: HTTP request failed! 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Direct reprogramming of human bone marrow stromal cells into functional renal cells using cell-free extracts |pdf=|usr=}}{{25754206 }} gab.com Text Direct reprogramming of human bone marrow stromal cells into functional renal cells using cell-free extracts JO: Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=25754206 #FOAvip The application of cell-based therapies in regenerative medicine is gaining recognition. Here, we show that human bone marrow stromal cells (BMSCs), also known as bone-marrow-derived mesenchymal cells, can be reprogrammed into renal proximal tubular-like epithelial cells using cell-free extracts. Streptolysin-O-permeabilized BMSCs exposed to HK2-cell extracts underwent morphological changes-formation of "domes" and tubule-like structures-and acquired epithelial functional properties such as transepithelial-resistance, albumin-binding, and uptake and specific markers E-cadherin and aquaporin-1. Transmission electron microscopy revealed the presence of brush border microvilli and tight intercellular contacts. RNA sequencing showed tubular epithelial transcript abundance and revealed the upregulation of components of the EGFR pathway. Reprogrammed BMSCs integrated into self-forming kidney tissue and formed tubular structures. Reprogrammed BMSCs infused in immunodeficient mice with cisplatin-induced acute kidney injury engrafted into proximal tubuli, reduced renal injury and improved function. Thus, reprogrammed BMSCs are a promising cell resource for future cell therapy. Twit Text FOAVip Direct reprogramming of human bone marrow stromal cells into functional renal cells using cell-free extracts ????Stem Cell Reports http://www.kidney.de/pget.php?&tw=1&pmid=25754206 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25754206 #FOAvip English Wikipedia <ref>{{Cite pmid|25754206 }}</ref> Direct reprogramming of human bone marrow stromal cells into functional renal cells using cell-free extracts #MMPMID25754206 Papadimou E ; Morigi M ; Iatropoulos P ; Xinaris C ; Tomasoni S ; Benedetti V ; Longaretti L ; Rota C ; Todeschini M ; Rizzo P ; Introna M ; Grazia de Simoni M ; Remuzzi G ; Goligorsky MS ; Benigni A Stem Cell Reports 2015[Apr]; 4 (4 ): 685-98 PMID25754206 show ga The application of cell-based therapies in regenerative medicine is gaining recognition. Here, we show that human bone marrow stromal cells (BMSCs), also known as bone-marrow-derived mesenchymal cells, can be reprogrammed into renal proximal tubular-like epithelial cells using cell-free extracts. Streptolysin-O-permeabilized BMSCs exposed to HK2-cell extracts underwent morphological changes-formation of "domes" and tubule-like structures-and acquired epithelial functional properties such as transepithelial-resistance, albumin-binding, and uptake and specific markers E-cadherin and aquaporin-1. Transmission electron microscopy revealed the presence of brush border microvilli and tight intercellular contacts. RNA sequencing showed tubular epithelial transcript abundance and revealed the upregulation of components of the EGFR pathway. Reprogrammed BMSCs integrated into self-forming kidney tissue and formed tubular structures. Reprogrammed BMSCs infused in immunodeficient mice with cisplatin-induced acute kidney injury engrafted into proximal tubuli, reduced renal injury and improved function. Thus, reprogrammed BMSCs are a promising cell resource for future cell therapy. |*Cell Differentiation [MESH] |*Cellular Reprogramming [MESH] |Animals [MESH] |Cell Line, Transformed [MESH] |Cell-Free System [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |In Vitro Techniques [MESH] |Kidney Tubules, Proximal/cytology [MESH] |Kidney/*cytology [MESH] |Mesenchymal Stem Cell Transplantation [MESH] |Mesenchymal Stem Cells/*cytology/*metabolism/ultrastructure [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH]Direct reprogramming of human bone marrow stromal cells into functiona(epmc).pdf DeepDyve Pubget Overpricing