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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Kidney+J
2012 ; 5
(6
): 566-71
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Denosumab for treatment of immobilization-related hypercalcaemia in a patient
with advanced renal failure
#MMPMID26069803
de Beus E
; Boer WH
Clin Kidney J
2012[Dec]; 5
(6
): 566-71
PMID26069803
show ga
We describe the case of a young adult with immobilization-related hypercalcaemia
and advanced renal insufficiency. Because of the uncertain safety profile of
bisphosphonates in such patients, only a low dose of pamidronate was administered
twice. This did not result in a sufficient decrease in the serum calcium
concentration nor was the decrease sustained. We decided to administer a single
dose of denosumab, a monoclonal antibody against the receptor activator of
nuclear factor-?B ligand, a new antiresorptive agent registered for use in
osteoporosis. This resulted in rapid and sustained decrease in the serum calcium
concentration. Transient hypocalcaemia ensued with normalization after vitamin D
supplementation. Furthermore, we summarize what is known about hypercalcaemia
caused by immobilization.