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10.1097/INF.0000000000000608 http://scihub22266oqcxt.onion/10.1097/INF.0000000000000608 C4400231!4400231!25356953     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Infect+Dis+J 2015 ; 34 (5): 463-8 Nephropedia Template TP {{tp|p=25356953|t=2015. Streptococcal Pharyngitis in Schoolchildren in Bamako, Mali |pdf=|usr=}}{{25356953}} gab.com Text Streptococcal Pharyngitis in Schoolchildren in Bamako, Mali JO: Pediatr Infect Dis J http://www.kidney.de/pget.php?&tw=1&pmid=25356953 #FOAvip Background: Group A streptococcus (GAS) pharyngitis is associated with high rates of rheumatic heart disease (RHD) in developing countries. We sought to identify guidelines for empiric treatment of pharyngitis in low resource settings. To inform the design of GAS vaccines, we determined the emm types associated with pharyngitis among African schoolchildren. Methods: Surveillance for pharyngitis was conducted among children 5 to 16 years of age attending schools in Bamako, Mali. Students were encouraged to visit a study clinician when they had a sore throat. Enrollees underwent evaluation and throat swab for isolation of GAS. Strains were emm typed by standard methods. Results: GAS was isolated from 449 (25.5%) of the 1,759 sore throat episodes. Painful cervical adenopathy identified 403 children (89.8%) with GAS infection and was absent in 369 uninfected children (28.2%). Emm type was determined in 396 (88.2%) of the 449 culture-positive children; 70 types were represented and 14 types accounted for 49% of isolates. Based on the proportion of the 449 isolates bearing emm types included in the 30-valent vaccine (31.0%) plus non-vaccine types previously shown to react to vaccine-induced bactericidal antibodies (44.1%), the vaccine could protect against almost 75% of GAS infections among Bamako schoolchildren. Conclusions: Two promising strategies could reduce RHD in low resource settings. Administering antibiotics to children with sore throat and tender cervical adenopathy could treat most GAS-positive children while reducing use of unnecessary antibiotics for uninfected children. Broad coverage against M types associated with pharyngitis in Bamako schoolchildren might be achieved with the 30-valent GAS vaccine under development. Twit Text FOAVip Streptococcal Pharyngitis in Schoolchildren in Bamako, Mali ????Pediatr Infect Dis J http://www.kidney.de/pget.php?&tw=1&pmid=25356953 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25356953 #FOAvip English Wikipedia <ref>{{Cite pmid|25356953}}</ref> Streptococcal Pharyngitis in Schoolchildren in Bamako, Mali #MMPMID25356953 Tapia MD; Sow SO; Tamboura B; Keita MM; Berthe A; Samake M; Nataro JP; Onwuchekwa UO; Penfound TA; Blackwelder W; Dale JB; Kotloff KL Pediatr Infect Dis J 2015[May]; 34 (5): 463-8 PMID25356953show ga Background: Group A streptococcus (GAS) pharyngitis is associated with high rates of rheumatic heart disease (RHD) in developing countries. We sought to identify guidelines for empiric treatment of pharyngitis in low resource settings. To inform the design of GAS vaccines, we determined the emm types associated with pharyngitis among African schoolchildren. Methods: Surveillance for pharyngitis was conducted among children 5 to 16 years of age attending schools in Bamako, Mali. Students were encouraged to visit a study clinician when they had a sore throat. Enrollees underwent evaluation and throat swab for isolation of GAS. Strains were emm typed by standard methods. Results: GAS was isolated from 449 (25.5%) of the 1,759 sore throat episodes. Painful cervical adenopathy identified 403 children (89.8%) with GAS infection and was absent in 369 uninfected children (28.2%). Emm type was determined in 396 (88.2%) of the 449 culture-positive children; 70 types were represented and 14 types accounted for 49% of isolates. Based on the proportion of the 449 isolates bearing emm types included in the 30-valent vaccine (31.0%) plus non-vaccine types previously shown to react to vaccine-induced bactericidal antibodies (44.1%), the vaccine could protect against almost 75% of GAS infections among Bamako schoolchildren. Conclusions: Two promising strategies could reduce RHD in low resource settings. Administering antibiotics to children with sore throat and tender cervical adenopathy could treat most GAS-positive children while reducing use of unnecessary antibiotics for uninfected children. Broad coverage against M types associated with pharyngitis in Bamako schoolchildren might be achieved with the 30-valent GAS vaccine under development. äStreptococcal Pharyngitis in Schoolchildren in Bamako, Mali (epmc).pdf DeepDyve Pubget Overpricing