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10.1371/journal.pone.0123572

http://scihub22266oqcxt.onion/10.1371/journal.pone.0123572
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C4400137!4400137!25881125
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suck abstract from ncbi


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pmid25881125      PLoS+One 2015 ; 10 (4): ä
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  • Anti-C1q Antibodies as a Follow-Up Marker in SLE Patients #MMPMID25881125
  • Bock M; Heijnen I; Trendelenburg M
  • PLoS One 2015[]; 10 (4): ä PMID25881125show ga
  • In cross-sectional studies autoantibodies against complement C1q (anti-C1q) were found to be highly associated with active lupus nephritis. The aim of this retrospective study was to determine the value of anti-C1q as follow-up marker of disease activity and renal involvement in patients with systemic lupus erythematosus (SLE). Fifty-two patients with SLE and a minimum of three anti-C1q measurements during follow-up were analyzed. Anti-C1q levels correlated with global disease activity scores. In subgroup analyses, patients without renal involvement did not show a significant correlation between anti-C1q levels and disease activity. In contrast, in patients with renal involvement, anti-C1q levels correlated well with global disease activity. In addition, a positive correlation with the urine protein-to-creatinine ratio and anti-dsDNA antibody levels as well as a negative correlation with complement levels was observed. Anti-C1q antibodies were found to strongly correlate with parameters of SLE disease activity during follow-up, in particular with regard to renal involvement.
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