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A new strategy for label-free detection of lymphoma cancer cells #MMPMID25909019
Martucci NM; Rea I; Ruggiero I; Terracciano M; De Stefano L; Migliaccio N; Palmieri C; Scala G; Arcari P; Rendina I; Lamberti A
Biomed Opt Express 2015[Apr]; 6 (4): 1353-62 PMID25909019show ga
In this paper, a new strategy for highly selective and sensitive direct detection of lymphoma cells by exploiting the interaction between a peptide and its B-cell receptor, has been evaluated. In particular, an idiotype peptide, able to specifically bind the B-cell receptor of A20 cells in mice engrafted with A20 lymphoma, has been used as molecular probe. The new detection technique has been demonstrated on a planar crystalline silicon chip. Coverage of 85% of silicon surface and detection efficiency of 8.5 × 10?3 cells/?m2 were obtained. The recognition strategy promises to extend its application in studying the interaction between ligands and their cell-surface receptors.