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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Oncol
2015 ; 22
(2
): 133-43
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Canadian consensus recommendations on the management of venous thromboembolism in
patients with cancer Part 1: prophylaxis
#MMPMID25908912
Easaw JC
; Shea-Budgell MA
; Wu CM
; Czaykowski PM
; Kassis J
; Kuehl B
; Lim HJ
; MacNeil M
; Martinusen D
; McFarlane PA
; Meek E
; Moodley O
; Shivakumar S
; Tagalakis V
; Welch S
; Kavan P
Curr Oncol
2015[Apr]; 22
(2
): 133-43
PMID25908912
show ga
Patients with cancer are at increased risk of venous thromboembolism (vte).
Anticoagulation therapy has been shown to prevent vte; however, unique clinical
circumstances in patients with cancer can often complicate the decisions
surrounding the administration of prophylactic anticoagulation. No national
Canadian guidelines on the prevention of cancer-associated thrombosis have been
published. We therefore aimed to develop a consensus-based, evidence-informed
guideline on the topic. PubMed was searched for clinical trials and meta-analyses
published between 2002 and 2013. Reference lists of key articles were
hand-searched for additional publications. Content experts from across Canada
were assembled to review the evidence and make recommendations. Low molecular
weight heparin can be used prophylactically in cancer patients at high risk of
developing vte. Direct oral anticoagulants are not recommended for vte
prophylaxis at this time. Specific clinical scenarios, including renal
insufficiency, thrombocytopenia, liver disease, and obesity can warrant
modifications in the administration of prophylactic anticoagulant therapy. There
is no evidence to support the monitoring of anti-factor Xa levels in clinically
stable cancer patients receiving prophylactic anticoagulation; however, factor Xa
levels could be checked at baseline and periodically in patients with renal
insufficiency. The use of anticoagulation therapy to prolong survival in cancer
patients without the presence of risk factors for vte is not recommended.