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10.3389/fphys.2015.00103 http://scihub22266oqcxt.onion/10.3389/fphys.2015.00103 C4399208!4399208!25932013     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Physiol 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=25932013|t=2015. Dopaminergic signaling within the primary cilia in the renovascular system |pdf=|usr=}}{{25932013}} gab.com Text Dopaminergic signaling within the primary cilia in the renovascular system JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25932013 #FOAvip Activation of dopamine receptor type-5 (DR5) has been known to reduce systemic blood pressure, most likely by increasing renal vasodilation and enhancing natriuresis in the kidney. However, the mechanism of DR5 in natriuresis and vasodilation was not clearly known. We have previously shown that DR5 is localized to primary cilia of proximal renal epithelial and vascular endothelial cells. We here show that selective activation of DR5 specifically induces calcium influx only in the primary cilia, whereas non-selective activation of dopamine receptor induces calcium fluxes in both cilioplasm and cytoplasm. Cilia-independent signaling induced by thrombin only shows calcium signaling within cytoplasm. Furthermore, calcium activation in the cilioplasm by DR5 increases length and mechanosensory function of primary cilia, leading to a greater response to fluid-shear stress. We therefore propose a new mechanism by which DR5 induces vasodilation via chemical and mechanical properties that are specific to primary cilia. Twit Text FOAVip Dopaminergic signaling within the primary cilia in the renovascular system ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25932013 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25932013 #FOAvip English Wikipedia <ref>{{Cite pmid|25932013}}</ref> Dopaminergic signaling within the primary cilia in the renovascular system #MMPMID25932013 Atkinson KF; Kathem SH; Jin X; Muntean BS; Abou-Alaiwi WA; Nauli AM; Nauli SM Front Physiol 2015[]; 6 (ä): ä PMID25932013show ga Activation of dopamine receptor type-5 (DR5) has been known to reduce systemic blood pressure, most likely by increasing renal vasodilation and enhancing natriuresis in the kidney. However, the mechanism of DR5 in natriuresis and vasodilation was not clearly known. We have previously shown that DR5 is localized to primary cilia of proximal renal epithelial and vascular endothelial cells. We here show that selective activation of DR5 specifically induces calcium influx only in the primary cilia, whereas non-selective activation of dopamine receptor induces calcium fluxes in both cilioplasm and cytoplasm. Cilia-independent signaling induced by thrombin only shows calcium signaling within cytoplasm. Furthermore, calcium activation in the cilioplasm by DR5 increases length and mechanosensory function of primary cilia, leading to a greater response to fluid-shear stress. We therefore propose a new mechanism by which DR5 induces vasodilation via chemical and mechanical properties that are specific to primary cilia. äDopaminergic signaling within the primary cilia in the renovascular sy(epmc).pdf DeepDyve Pubget Overpricing