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Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Transl+Res 2015 ; 7 (2): 232-41 Nephropedia Template TP
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Identification and characterization of CD4+AT2+ T lymphocyte population in human thoracic aortic aneurysm #MMPMID25901193
Wang C; Wu T; Hu X; Huang R; Lian F; Wang W; Feng Y; Xie B; Hu Z; Zhai X; Liu J; Gu J; Chen Y; Li J; Xue S
Am J Transl Res 2015[]; 7 (2): 232-41 PMID25901193show ga
Thoracic aortic aneurysm (TAA) is progressive fatal aortic pathological dilation. However, the underlying molecular mechanisms are still largely unknown. Evidences suggest that endothelial cells and renin-angiotensin system may participate in the pathogenesis of TAA. This study aimed to investigate whether angiotensin II type 2 receptor (AT2) positive cells are involved in TAA formation. The mRNA level of AT2 is dramatically elevated in TAA compared with in controls. CD4+AT2+ cells increased in both aortic wall and circulation of TAA patients. The levels of IL-1? and IL-17B in CD4+AT2+ cells were lower than those in CD4+AT2- cells. When compared with endothelial cells (ECs) cultured alone, CD4+AT2+ cells showed an inhibitory effect on proliferation and MMP2 expression in ECs, but CD4+AT2- cells promoted proliferation and MMP2 expression in ECs. Both CD4+AT2+ and CD4+AT2- cells suppressed apoptosis of ECs. In conclusion, we have identified a novel population of CD4+AT2+ T lymphocytes that show protective effect in TAA through inhibition of growth, apoptosis, and MMP2 expression in ECs.