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http://scihub22266oqcxt.onion/ C4399085!4399085!25901190     free     free     free       Am+J+Transl+Res 2015 ; 7 (2): 175-93 Nephropedia Template TP {{tp|p=25901190|t=2015. Diverse involvement of EZH2 in cancer epigenetics |pdf=|usr=}}{{25901190}} gab.com Text Diverse involvement of EZH2 in cancer epigenetics JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=25901190 #FOAvip EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target genes via local chromatin reorganization. Numerous evidences show that EZH2 plays a critical role in cancer initiation, progression and metastasis, as well as in cancer stem cell biology. Indeed, EZH2 dysregulation alters gene expression programs in various cancer types. The molecular mechanisms responsible for EZH2 alteration appear to be diverse and depending on the type of cancer. Furthermore, accumulating evidences indicate that EZH2 could also act as a PRC2-independent transcriptional activator in cancer. In this review, we address the current understanding of the oncogenic role of EZH2, including the mechanisms of EZH2 dysregulation in cancer and progresses in therapeutic approaches targeting EZH2. Twit Text FOAVip Diverse involvement of EZH2 in cancer epigenetics ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=25901190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25901190 #FOAvip English Wikipedia <ref>{{Cite pmid|25901190}}</ref> Diverse involvement of EZH2 in cancer epigenetics #MMPMID25901190 Völkel P; Dupret B; Le Bourhis X; Angrand PO Am J Transl Res 2015[]; 7 (2): 175-93 PMID25901190show ga EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target genes via local chromatin reorganization. Numerous evidences show that EZH2 plays a critical role in cancer initiation, progression and metastasis, as well as in cancer stem cell biology. Indeed, EZH2 dysregulation alters gene expression programs in various cancer types. The molecular mechanisms responsible for EZH2 alteration appear to be diverse and depending on the type of cancer. Furthermore, accumulating evidences indicate that EZH2 could also act as a PRC2-independent transcriptional activator in cancer. In this review, we address the current understanding of the oncogenic role of EZH2, including the mechanisms of EZH2 dysregulation in cancer and progresses in therapeutic approaches targeting EZH2. äDiverse involvement of EZH2 in cancer epigenetics (epmc).pdf DeepDyve Pubget Overpricing