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10.1111/cas.12587 http://scihub22266oqcxt.onion/10.1111/cas.12587 C4399022!4399022 !25495189     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25495189 &cmd=llinks): Failed to open stream: HTTP request failed! 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TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma |pdf=|usr=}}{{25495189 }} gab.com Text TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25495189 #FOAvip The transcriptional coactivator with PDZ binding motif (TAZ) has been reported to be one of the nuclear effectors of Hippo-related pathways. TAZ is expressed in many primary tumors and could regulate many biological processes. However, little is known about the role of TAZ in hepatocellular carcinoma (HCC). In the current study, we show that TAZ regulates cellular proliferation and epithelial-mesenchymal transition (EMT) of HCC. TAZ is overexpressed in HCC tissues and cell lines and upregulation of TAZ correlates with a lower overall survival rate of HCC patients after hepatic resection. TAZ knockdown results in inhibition of cancer cell proliferation through decreases in expression of stem cell markers (OCT4, Nanog, and SOX2). Reduction in HCC cell migration and invasion is also evident through reversal of EMT by increases E-cadherin expression, decreases in N-cadherin, vimentin, Snail, and Slug expression, and suppression of MMP-2 and MMP-9 expression. In a xenograft tumorigenicity model, TAZ knockdown could effectively inhibit tumor growth and metastasis through reversal of the EMT pathway. In conclusion, TAZ is associated with the proliferation and invasiveness of HCC cells, and the TAZ gene may contribute to a novel therapeutic approach against HCC. Twit Text FOAVip TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=25495189 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25495189 #FOAvip English Wikipedia <ref>{{Cite pmid|25495189 }}</ref> TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma #MMPMID25495189 Xiao H ; Jiang N ; Zhou B ; Liu Q ; Du C Cancer Sci 2015[Feb]; 106 (2 ): 151-9 PMID25495189 show ga The transcriptional coactivator with PDZ binding motif (TAZ) has been reported to be one of the nuclear effectors of Hippo-related pathways. TAZ is expressed in many primary tumors and could regulate many biological processes. However, little is known about the role of TAZ in hepatocellular carcinoma (HCC). In the current study, we show that TAZ regulates cellular proliferation and epithelial-mesenchymal transition (EMT) of HCC. TAZ is overexpressed in HCC tissues and cell lines and upregulation of TAZ correlates with a lower overall survival rate of HCC patients after hepatic resection. TAZ knockdown results in inhibition of cancer cell proliferation through decreases in expression of stem cell markers (OCT4, Nanog, and SOX2). Reduction in HCC cell migration and invasion is also evident through reversal of EMT by increases E-cadherin expression, decreases in N-cadherin, vimentin, Snail, and Slug expression, and suppression of MMP-2 and MMP-9 expression. In a xenograft tumorigenicity model, TAZ knockdown could effectively inhibit tumor growth and metastasis through reversal of the EMT pathway. In conclusion, TAZ is associated with the proliferation and invasiveness of HCC cells, and the TAZ gene may contribute to a novel therapeutic approach against HCC. |Animals [MESH] |Biomarkers, Tumor/genetics [MESH] |Cadherins/genetics [MESH] |Carcinoma, Hepatocellular/*genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation/*genetics [MESH] |Epithelial-Mesenchymal Transition/*genetics [MESH] |Homeodomain Proteins [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/*genetics [MESH] |Liver Neoplasms/*genetics/metabolism [MESH] |Matrix Metalloproteinase 2/genetics [MESH] |Matrix Metalloproteinase 9/genetics [MESH] |Mice [MESH] |Nanog Homeobox Protein [MESH] |Octamer Transcription Factor-3 [MESH] |SOXB1 Transcription Factors [MESH] |Signal Transduction/genetics [MESH] |Snail Family Transcription Factors [MESH] |Stem Cells/metabolism [MESH] |Survival Rate [MESH] |Trans-Activators [MESH] |Transcription Factors [MESH] |Transcriptional Coactivator with PDZ-Binding Motif Proteins [MESH] |Up-Regulation/genetics [MESH]TAZ regulates cell proliferation and epithelial-mesenchymal transition(epmc).pdf DeepDyve Pubget Overpricing