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10.1097/MPA.0000000000000308 http://scihub22266oqcxt.onion/10.1097/MPA.0000000000000308 C4399019!4399019 !25875801     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25875801 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pancreas 2015 ; 44 (4 ): 636-47 Nephropedia Template TP {{tp|p=25875801 |t=2015. Metformin suppresses pancreatic tumor growth with inhibition of NF?B/STAT3 inflammatory signaling |pdf=|usr=}}{{25875801 }} gab.com Text Metformin suppresses pancreatic tumor growth with inhibition of NF B/STAT3 inflammatory signaling JO: Pancreas http://www.kidney.de/pget.php?&tw=1&pmid=25875801 #FOAvip OBJECTIVES: To further elucidate the anticancer mechanisms of metformin against pancreatic cancer, we evaluated the inhibitory effects of metformin on pancreatic tumorigenesis in a genetically engineered mouse model and investigated its possible anti-inflammatory and antiangiogenesis effects. METHODS: Six-week-old LSL-Kras;Trp53 mice (10 per group) were administered once daily intraperitoneally with saline (control) for 1 week or metformin (125 mg/kg) for 1 week (Met_1wk) or 3 weeks (Met_3wk) before tumor initiation. All mice continued with their respective injections for 6 weeks after tumor initiation. Molecular changes were evaluated through quantitative polymerase chain reaction, immunohistochemistry, and Western blotting. RESULTS: At euthanasia, pancreatic tumor volume in the Met_1wk (median, 181.8 mm) and Met_3wk (median, 137.9 mm) groups was significantly lower than those in the control group (median, 481.1 mm; P = 0.001 and 0.0009, respectively). No significant difference was observed between the Met_1wk and Met_3wk groups (P = 0.51). These results were further confirmed using tumor weight and tumor burden measurements. Furthermore, metformin treatment decreased the phosphorylation of nuclear factor ?B and signal transducer and activator of transcription 3 as well as the expression of specificity protein 1 transcription factor and several nuclear factor ?B-regulated genes. CONCLUSIONS: Metformin may inhibit pancreatic tumorigenesis by modulating multiple molecular targets in inflammatory pathways. Twit Text FOAVip Metformin suppresses pancreatic tumor growth with inhibition of NF B/STAT3 inflammatory signaling ????Pancreas http://www.kidney.de/pget.php?&tw=1&pmid=25875801 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25875801 #FOAvip English Wikipedia <ref>{{Cite pmid|25875801 }}</ref> Metformin suppresses pancreatic tumor growth with inhibition of NF?B/STAT3 inflammatory signaling #MMPMID25875801 Tan XL ; Bhattacharyya KK ; Dutta SK ; Bamlet WR ; Rabe KG ; Wang E ; Smyrk TC ; Oberg AL ; Petersen GM ; Mukhopadhyay D Pancreas 2015[May]; 44 (4 ): 636-47 PMID25875801 show ga OBJECTIVES: To further elucidate the anticancer mechanisms of metformin against pancreatic cancer, we evaluated the inhibitory effects of metformin on pancreatic tumorigenesis in a genetically engineered mouse model and investigated its possible anti-inflammatory and antiangiogenesis effects. METHODS: Six-week-old LSL-Kras;Trp53 mice (10 per group) were administered once daily intraperitoneally with saline (control) for 1 week or metformin (125 mg/kg) for 1 week (Met_1wk) or 3 weeks (Met_3wk) before tumor initiation. All mice continued with their respective injections for 6 weeks after tumor initiation. Molecular changes were evaluated through quantitative polymerase chain reaction, immunohistochemistry, and Western blotting. RESULTS: At euthanasia, pancreatic tumor volume in the Met_1wk (median, 181.8 mm) and Met_3wk (median, 137.9 mm) groups was significantly lower than those in the control group (median, 481.1 mm; P = 0.001 and 0.0009, respectively). No significant difference was observed between the Met_1wk and Met_3wk groups (P = 0.51). These results were further confirmed using tumor weight and tumor burden measurements. Furthermore, metformin treatment decreased the phosphorylation of nuclear factor ?B and signal transducer and activator of transcription 3 as well as the expression of specificity protein 1 transcription factor and several nuclear factor ?B-regulated genes. CONCLUSIONS: Metformin may inhibit pancreatic tumorigenesis by modulating multiple molecular targets in inflammatory pathways. |Animals [MESH] |Antineoplastic Agents/*pharmacology/therapeutic use [MESH] |Biomarkers, Tumor/*antagonists & inhibitors/metabolism [MESH] |Blotting, Western [MESH] |Drug Administration Schedule [MESH] |Female [MESH] |Immunohistochemistry [MESH] |Injections, Intraperitoneal [MESH] |Male [MESH] |Metformin/*pharmacology/therapeutic use [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |NF-kappa B/*antagonists & inhibitors/metabolism [MESH] |Pancreatic Neoplasms/*drug therapy/metabolism/pathology [MESH] |Polymerase Chain Reaction [MESH] |Random Allocation [MESH] |STAT3 Transcription Factor/*antagonists & inhibitors/metabolism [MESH] |Signal Transduction/drug effects [MESH]Metformin suppresses pancreatic tumor growth with inhibition of NF?B/S(epmc).pdf DeepDyve Pubget Overpricing