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10.1038/ncomms7081 http://scihub22266oqcxt.onion/10.1038/ncomms7081 C4398998!4398998!25603276     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): 6081 Nephropedia Template TP {{tp|p=25603276|t=2015. The mitochondrial uniporter controls fight or flight heart rate increases |pdf=|usr=}}{{25603276}} gab.com Text The mitochondrial uniporter controls fight or flight heart rate increases JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25603276 #FOAvip Heart rate increases are a fundamental adaptation to physiological stress, while inappropriate heart rate increases are resistant to current therapies. However, the metabolic mechanisms driving heart rate acceleration in cardiac pacemaker cells remain incompletely understood. The mitochondrial calcium uniporter (MCU) facilitates calcium entry into the mitochondrial matrix to stimulate metabolism. We developed mice with myocardial MCU inhibition by transgenic expression of a dominant negative (DN) MCU. Here we show that DN-MCU mice had normal resting heart rates but were incapable of physiological fight or flight heart rate acceleration. We found MCU function was essential for rapidly increasing mitochondrial calcium in pacemaker cells and that MCU enhanced oxidative phoshorylation was required to accelerate reloading of an intracellular calcium compartment prior to each heartbeat. Our findings show the MCU is necessary for complete physiological heart rate acceleration and suggest MCU inhibition could reduce inappropriate heart rate increases without affecting resting heart rate. Twit Text FOAVip The mitochondrial uniporter controls fight or flight heart rate increases ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25603276 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25603276 #FOAvip English Wikipedia <ref>{{Cite pmid|25603276}}</ref> The mitochondrial uniporter controls fight or flight heart rate increases #MMPMID25603276 Wu Y; Rasmussen TP; Koval OM; Joiner MlA; Hall DD; Chen B; Luczak ED; Wang Q; Rokita AG; Wehrens XHT; Song L; Anderson ME Nat Commun 2015[]; 6 (ä): 6081 PMID25603276show ga Heart rate increases are a fundamental adaptation to physiological stress, while inappropriate heart rate increases are resistant to current therapies. However, the metabolic mechanisms driving heart rate acceleration in cardiac pacemaker cells remain incompletely understood. The mitochondrial calcium uniporter (MCU) facilitates calcium entry into the mitochondrial matrix to stimulate metabolism. We developed mice with myocardial MCU inhibition by transgenic expression of a dominant negative (DN) MCU. Here we show that DN-MCU mice had normal resting heart rates but were incapable of physiological fight or flight heart rate acceleration. We found MCU function was essential for rapidly increasing mitochondrial calcium in pacemaker cells and that MCU enhanced oxidative phoshorylation was required to accelerate reloading of an intracellular calcium compartment prior to each heartbeat. Our findings show the MCU is necessary for complete physiological heart rate acceleration and suggest MCU inhibition could reduce inappropriate heart rate increases without affecting resting heart rate. äThe mitochondrial uniporter controls fight or flight heart rate increa(epmc).pdf DeepDyve Pubget Overpricing