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10.1016/j.cell.2015.02.015 http://scihub22266oqcxt.onion/10.1016/j.cell.2015.02.015 C4398973!4398973!25799385     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2015 ; 161 (2): 361-73 Nephropedia Template TP {{tp|p=25799385|t=2015. Inter-Cellular Forces Orchestrate Contact Inhibition of Locomotion |pdf=|usr=}}{{25799385}} gab.com Text Inter-Cellular Forces Orchestrate Contact Inhibition of Locomotion JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25799385 #FOAvip Contact inhibition of locomotion (CIL) is a multifaceted process that causes many cell types to repel each other upon collision. During development, this seemingly uncoordinated reaction is a critical driver of cellular dispersion within embryonic tissues. Here, we show that Drosophila hemocytes require a precisely orchestrated CIL response for their developmental dispersal. Hemocyte collision and subsequent repulsion involves a stereotyped sequence of kinematic stages that are modulated by global changes in cytoskeletal dynamics. Tracking actin retrograde flow within hemocytes in vivo reveals synchronous reorganization of colliding actin networks through engagement of an inter-cellular adhesion. This inter-cellular actin-clutch leads to a subsequent build-up in lamellar tension, triggering the development of a transient stress fiber, which orchestrates cellular repulsion. Our findings reveal that the physical coupling of the flowing actin networks during CIL acts as a mechanotransducer, allowing cells to haptically sense each other and coordinate their behaviors. Twit Text FOAVip Inter-Cellular Forces Orchestrate Contact Inhibition of Locomotion ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25799385 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25799385 #FOAvip English Wikipedia <ref>{{Cite pmid|25799385}}</ref> Inter-Cellular Forces Orchestrate Contact Inhibition of Locomotion #MMPMID25799385 Davis J; Luchici A; Mosis F; Thackery J; Salazar J; Mao Y; Dunn G; Betz T; Miodownik M; Stramer B Cell 2015[Apr]; 161 (2): 361-73 PMID25799385show ga Contact inhibition of locomotion (CIL) is a multifaceted process that causes many cell types to repel each other upon collision. During development, this seemingly uncoordinated reaction is a critical driver of cellular dispersion within embryonic tissues. Here, we show that Drosophila hemocytes require a precisely orchestrated CIL response for their developmental dispersal. Hemocyte collision and subsequent repulsion involves a stereotyped sequence of kinematic stages that are modulated by global changes in cytoskeletal dynamics. Tracking actin retrograde flow within hemocytes in vivo reveals synchronous reorganization of colliding actin networks through engagement of an inter-cellular adhesion. This inter-cellular actin-clutch leads to a subsequent build-up in lamellar tension, triggering the development of a transient stress fiber, which orchestrates cellular repulsion. Our findings reveal that the physical coupling of the flowing actin networks during CIL acts as a mechanotransducer, allowing cells to haptically sense each other and coordinate their behaviors. äInter-Cellular Forces Orchestrate Contact Inhibition of Locomotion (epmc).pdf DeepDyve Pubget Overpricing